您的位置：首页 > 产品中心 > GluN2B NMDA Receptor Antagonist, 93-31-Calbiochem
GluN2B NMDA Receptor Antagonist, 93-31-Calbiochem
产品别名
GluN2B NMDA Receptor Antagonist, 93-31-Calbiochem
(S)-N-(4-(3-(butyl(3,4-dichlorophenethyl)amino)-2-hydroxypropoxy)phenyl)methanesulfonamide
基本信息
| Empirical Formula【经验(实验)分子式】 | C22H30Cl2N2O4S |
| Molecular weight | 489.46 |
| General description【一般描述】 | A tertiary N-alkylamine that acts as a pH dependent antagonist of GluN2B-NMDA receptors. Shown to be about 10-fold more potent in ischemic tissue (pH 6.9) than in normal healthy tissue (pH 7.6) (IC50 = 190 nM and 1.8 µM, respectively). Effectively reduces the infarct volume in damaged brain tissue in a murine model of ischemic stroke (at 10 mg/kg, ED50 ≤ 1 mg/kg) without impairing coordination or motor function. Also displays binding to hERG (IC50 = 70 nM) and alpha1-adrenergic receptor (IC50 = 4.9 µM). |
| Biochem/physiol Actions【生化/生理作用】 | Reversible: yes Primary Target GluN2B NMDA Receptor |
| Warning【警告】 | Toxicity: Standard Handling (A) |
| Reconstitution【重悬】 | Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. |
| Other Notes【其他说明】 | Yuan, H., et al. 2015. Neuron.85, 1305. Tahirovic, Y., et al. 2008. J. Med. Chem.51, 5506. |
| Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | solid (sticky) |
| potency【效能】 | 0.19 μM IC50 |
| manufacturer/tradename | Calbiochem® |
| storage condition【储存条件】 | OK to freeze protect from light |
| color【颜色】 | light yellow to yellow |
| solubility【溶解性】 | DMSO: 100 mg/mL |
| storage temp.【储存温度】 | −20℃ |
| packaging【包装】 | Packaged under inert gas |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
