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Peroxiredoxin Inhibitor, Conoidin A-CAS 18080-67-6-Calbiochem
| 产品编号： | 4083592 |
| 规格： | A cell-permeable nematicidal compound that covalently binds to the peroxidatic cysteine of peroxiredoxin II in T. gondii and irreversibly blocks its hyperperoxidation activity (IC50 = 23 μM). |
| CAS NO： | 18080-67-6 |
| 包装规格： | 25 MG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
18080-67-6
Peroxiredoxin Inhibitor, Conoidin A-CAS 18080-67-6-Calbiochem
2,3- bis(Bromomethyl)quinoxaline-1,4-dioxide, Prx Inhibitor
2,3-bis(Bromomethyl)quinoxaline-1,4-dioxide, Prx Inhibitor
基本信息
| Empirical Formula【经验(实验)分子式】 | C10H8Br2N2O2 |
| Molecular weight | 347.99 |
| General description【一般描述】 | A cell-permeable dibromomethylquinoxaline-dioxide compound with nematicidal properties that covalently binds to the peroxidatic cysteine of peroxiredoxin II in Toxoplasma gondii (TgPrxII) and irreversibly blocks its hyperperoxidation activity (IC50 = 23 µM). Also shown to alkylate or crosslink catalytic cysteines of wild type AcePrx-1 in Ancylostoma ceylanicum and human PrxII and PrxIV to inhibit their catalytic activity with similar efficiency. Ineffective towards mitochondrial hPrxIII. A cell-permeable dibromomethylquinoxaline-dioxide compound with nematicidal properties that covalently binds to the peroxidatic cysteine of peroxiredoxin II in Toxoplasma gondii (TgPrxII) and irreversibly blocks its hyperperoxidation activity (IC50 = 23 µM). Also shown to alkylate or crosslink catalytic cysteines of wild type AcePrx-1 in Ancylostoma ceylanicum and human PrxII and PrxIV to inhibit their catalytic activity with similar efficiency. Ineffective towards mitochondrial hPrxIII. Please note that the molecular weight for this compound is batch-specific due to variable water content. |
| Biochem/physiol Actions【生化/生理作用】 | Cell permeable: yes Reversible: no Primary Target Peroxiredoxin Target IC50: 23 µM for blocking TgPrxII hyperperoxidation activity |
| Warning【警告】 | Toxicity: Standard Handling (A) |
| Reconstitution【重悬】 | Following reconstitution, aliquot and freeze (-70°C). Stock solutions are stable for up to 2 weeks at -70°C. Use only fresh DMSO for reconstitution. |
| Other Notes【其他说明】 | Nguyen, J.B., et al. 2013. Chem. Biol.20, 991. Haraldsen, J. D., et al. 2009. Org. Biomol. Chem.7, 3040. Carey, K.L., et al. 2004. Proc. Natl. Acad. Sci. USA101, 7433. |
| Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
| Assay【测定】 | ≥95% (NMR) |
| Quality Level【质量水平】 | 100 |
| form【形式】 | solid |
| manufacturer/tradename | Calbiochem® |
| storage condition【储存条件】 | OK to freeze desiccated protect from light |
| color【颜色】 | yellow-brown |
| solubility【溶解性】 | DMSO: 50 mg/mL |
| storage temp.【储存温度】 | −20℃ |
| InChI | 1S/C10H8Br2N2O2/c11-5-9-10(6-12)14(16)8-4-2-1-3-7(8)13(9)15/h1-4H,5-6H2 |
| InChI key | DQKNFTLRMZOAMG-UHFFFAOYSA-N |
| packaging【包装】 | Packaged under inert gas |
安全信息
| Hazard Statements | H413 |
| Precautionary Statements | P273 - P501 |
| Hazard Classifications【危险分类】 | Aquatic Chronic 4 |
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
