AAA-ATPase Drg1 Inhibitor, Diazaborine-Calbiochem

C₁₄H₁₃BN₂O₃S

300.14

A diazaborine derivative with anti-bacterial properties against a wide range of Gram-negative bacteria. Shown to target NAD(P)H-dependent enoyl acyl carrier protein reductase (ENR), which results in the inhibition of bacterial fatty acid synthase. Blocks the maturation of ribosomal RNA for the large 60S ribosomal subunit in yeast cells by binding to the D2 domain of AAA-ATPase Drg1 (K_i = 26 µM) resulting in reduced ATP hydrolysis and release of Rip24 from pre-60S particles.

Please note that the molecular weight for this compound is batch-specific due to variable water content.
A diazaborine derivative with anti-bacterial properties against a wide range of Gram-negative bacteria. Shown to target NAD(P)H-dependent enoyl acyl carrier protein reductase (ENR), which results in the inhibition of bacterial fatty acid synthase. Blocks the maturation of ribosomal RNA for the large 60S ribosomal subunit in yeast cells by binding to the D2 domain of AAA-ATPase Drg1 (K_i = 26 µM) resulting in reduced ATP hydrolysis and release of Rip24 from pre-60S particles.

Cell permeable: yes
Reversible: yes
Primary Target
Drg1 AAA-ATPase

Toxicity: Standard Handling (A)

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Loibl, M., et al. 2014. J. Biol. Chem. 289, 3913.
Pertschy B., et al. 2004. Mol. Cell. Biol. 24, 6476.
Baldock, C. et al. 1998. Biochem. Pharmacol. 55, 1541.
Grassberger M., et al. 1984. J Med Chem.27, 947.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

100

≥98% (HPLC)

powder

26 μM K_i

Calbiochem^®

OK to freeze
protect from light

white

DMSO: 100 mg/mL

2-8℃

Packaged under inert gas

11 - Combustible Solids

WGK 3