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InSolution MIF Antagonist, ISO-1-CAS 478336-92-4-Calbiochem
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| 产品编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
| 4083680 | 10 MG | 2270 |
产品别名
478336-92-4
InSolution MIF Antagonist, ISO-1-CAS 478336-92-4-Calbiochem
( S, R)-3-(4-Hydroxyphenyl)-4,5-dihydro-5-isoxazole acetic acid, methyl ester, Methyl 2-(3-(4-hydroxyphenyl)-4,5-dihydroisoxazol-5-yl)acetate, Macrophage Migration Inhibitory Factor Antagonist, ISO-1
(S,R)-3-(4-Hydroxyphenyl)-4,5-dihydro-5-isoxazole acetic acid, methyl ester, Methyl 2-(3-(4-hydroxyphenyl)-4,5-dihydroisoxazol-5-yl)acetate, Macrophage Migration Inhibitory Factor Antagonist, ISO-1
基本信息
| Empirical Formula【经验(实验)分子式】 | C12H13NO4 |
| Molecular weight | 235.24 |
| General description【一般描述】 | A cell-permeable isoxazoline compound that displays anti-inflammatory properties. Inhibits MIF dopachrome tautomerase activity by binding to its catalytic active site (IC50 = 7 µM for D-dopachrome tautomerase) and suppresses the production of TNFα, PGE2 and COX-2 in human monocytes and arachidonic acid in RAW 264.7 macrophages. Shown to exhibit antidiabetogenic properties in immunoinflammatory diabetic mouse model. |
| Biochem/physiol Actions【生化/生理作用】 | Cell permeable: yes Primary Target MIF dopachrome tautomerase |
| Warning【警告】 | Toxicity: Irritant (B) |
| Physical form【外形】 | A 50 mM (10 mg/850 µL) sterile-filtered solution of MIF Antagonist, ISO-1 (Cat. No. 475837) in DMSO. |
| Reconstitution【重悬】 | Following initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 1 year at -70°C. |
| Other Notes【其他说明】 | Cvetkovic, I., et al. 2005. Endocrinology146, 2942. Lubetsky, J.B., et al. 2002. J. Biol. Chem.277, 24976. |
| Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥95% (HPLC) |
| form【形式】 | liquid |
| manufacturer/tradename | Calbiochem® |
| storage condition【储存条件】 | OK to freeze avoid repeated freeze/thaw cycles desiccated (hygroscopic) protect from light |
| storage temp.【储存温度】 | −70℃ |
| packaging【包装】 | Packaged under inert gas |
安全信息
| Storage Class Code【储存分类代码】 | 10 - Combustible liquids |
| WGK | WGK 1 |
| Flash Point(F)【闪点(F)】 | 188.6 °F - (refers to pure substance) |
| Flash Point(C)【闪点(C)】 | 87 ℃ - (refers to pure substance) |
