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SNX-482-CAS 203460-30-4-Calbiochem
| 产品编号： | 4083740 |
| 规格： | A peptidyl toxin from venom of African tarantula, Hysterocrates gigas that acts as a high affinity, reversible blocker of Cav2.3 (α1E, R-type) channels (IC50 = 15-30 nM). |
| CAS NO： | 203460-30-4 |
| 包装规格： | 10 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品价格查看更多规格...
| 产品编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
| 4083740 | 10 μG | 2680 |
产品别名
203460-30-4
SNX-482-CAS 203460-30-4-Calbiochem
基本信息
| Empirical Formula【经验(实验)分子式】 | C192H274N52O60S7 |
| Molecular weight | 4495.00 |
| General description【一般描述】 | A peptidyl toxin present in the venom of African tarantula, Hysterocrates gigas that acts as a high affinity, reversible blocker of Cav2.3 (α1E, R-type) channels (IC50 = 15-30 nM). The inhibition appears to be voltage-dependent. At lower concentrations it is also shown to block native R-type Ca2+ current in rat neurohypophyseal nerve terminals, however, these effects are not observed at higher concentrations. Does not affect Na+ or K+ currents in several cultured cell types (~ 500 nM). |
| Biochem/physiol Actions【生化/生理作用】 | Primary Target Cav2.3 channels |
| Warning【警告】 | Toxicity: Standard Handling (A) |
| Sequence【序列】 | GVDKAGCRYMFGGCSVNDDCCPRLGCHSLF→SYCAWDLTFSD (difulfid bond: 7-21, 14-26, 20-33) |
| Reconstitution【重悬】 | Following reconstitution, aliquot and freeze(-20°C). Stock solutions are stable for up to 3 months at -20°C. |
| Other Notes【其他说明】 | Abitbol, K. et al. 2012. J. Physiol.590, 2977. Newcomb, R., et al., 1998. Biochemistry.37, 15353. |
| Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | solid |
| potency【效能】 | 15-30 nM IC50 |
| manufacturer/tradename | Calbiochem® |
| storage condition【储存条件】 | OK to freeze protect from light |
| color【颜色】 | white |
| storage temp.【储存温度】 | −20℃ |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
