BTS-CAS 1576-37-0-Calbiochem

C₁₄H₁₅NO₂S

261.34

An aryl sulphonamide that acts as a potent inhibitor of Ca²⁺-stimulated myosin S1 actin-stimulated ATPase activity (IC₅₀ = ~5 µM). Also blocks actin-stimulated ATPase activity with similar potency (IC₅₀ = 5 µM). Reversibly blocks gliding motility of skeletal muscle myosin (IC₅₀<2 µM). Less effective in suppressing contraction in rat myocardial and rabbit slow twitch muscle compared to skeletal muscle. Does not inhibit platelet myosin II.
A potent inhibitor of Ca²⁺-stimulated myosin S1 ATPase (IC₅₀ = ~ 5 µM) and reversibly blocks the gliding motility. It also weakens myosin’s interaction with F-actin. Much less effective in suppressing contraction in rat myocardial or rabbit slow twitch muscle and has no effect on platelet myosin II.

Target IC₅₀: ~5 µM against Ca2+-stimulated myosin S1 ATPase
Product does not compete with ATP.
Primary Target
Ca²⁺-stimulated myosin S1 ATPase
Cell permeable: no
Reversible: yes

Toxicity: Standard Handling (A)

Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Cheung, A., et al. 2002. Nat. Cell Biol.4, 83.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

100

≥95% (HPLC)

crystalline solid

Calbiochem^®

OK to freeze
protect from light

white

DMSO: 200 mg/mL

ambient

2-8℃

1S/C14H15NO2S/c1-12-7-9-14(10-8-12)18(16,17)15-11-13-5-3-2-4-6-13/h2-10,15H,11H2,1H3

WTHKAJZQYNKTCJ-UHFFFAOYSA-N

5 mg in Plastic ampoule
Packaged under inert gas

11 - Combustible Solids

WGK 3