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CCR2 Antagonist-CAS 445479-97-0-Calbiochem
| 产品编号： | 4083815 |
| 规格： | The CCR2 Antagonist, also referenced under CAS 445479-97-0, controls the biological activity of CCR2. |
| CAS NO： | 445479-97-0 |
| 包装规格： | 5 MG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
445479-97-0
CCR2 Antagonist-CAS 445479-97-0-Calbiochem
2-((Isopropylaminocarbonyl)amino)-N-(2-((cis-2-((4-(methylthio)benzoyl)amino)cyclohexyl)amino)-2-oxoethyl)-5-(trifluoromethyl)-benzamide, CC Chemokine Receptor 2 Antagonist
基本信息
| Empirical Formula【经验(实验)分子式】 | C28H34F3N5O4S |
| Molecular weight | 593.66 |
| General description【一般描述】 | A cis-diamidocyclohexyl urea compound that potently competes against MCP-1 binding to CCR2 (IC50 = 5.1 nM) and effectively inhibits MCP-1/CCR2-mediated PBMCs Ca+2 flux and chemotaxis (IC50 = 18 and 1 nM, respectively), while showing much less effect against eotaxin binding to CCR3 (37% inhibition at 10 µM). Mutageneis analysis indicates CCR2 Thr292 is critical in maintaining the high affinity antagonist binding. |
| Warning【警告】 | Toxicity: Standard Handling (A) |
| Preparation Note【制备说明】 | Gentle warming, rapid stirring, and/or sonication may be required for complete solubilization. |
| Reconstitution【重悬】 | Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. |
| Other Notes【其他说明】 | Cherney, R.J., et al. 2008. J. Med. Chem.51, 721. |
| Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥97% (racemic mixture, HPLC) |
| form【形式】 | solid |
| manufacturer/tradename | Calbiochem® |
| storage condition【储存条件】 | OK to freeze desiccated (hygroscopic) protect from light |
| color【颜色】 | white |
| solubility【溶解性】 | ethanol: 6 mg/mL DMSO: 60 mg/mL |
| shipped in【运输】 | ambient |
| storage temp.【储存温度】 | 2-8℃ |
| packaging【包装】 | 5 mg in Plastic ampoule Packaged under inert gas |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
