COX-2 Inhibitor I-CAS 416901-58-1-Calbiochem

C₁₈H₁₆ClNO₄S

377.84

A cell-permeable potent, selective inhibitor of cyclooxygenase-2 (COX-2) (IC₅₀ = 650 nM, human monocytes COX-2). Shown to specifically inhibit COX-2 in human whole blood (IC₅₀ = 4.3 µM). Displays only weak inhibitory activity against COX-1 from human platelets (19% inhibition at 10 µM) and in whole blood (25% inhibition at 100 µM).
A cell-permeable potent and selective inhibitor of COX-2 from human monocytes (IC₅₀ = 650 nM) and in whole blood (IC₅₀ = 4.3 µM). Displays only very weak activity against COX-1 from human platelets (IC₅₀ >10 µM) and in whole blood (IC₅₀ >100 µM).

Cell permeable: yes
Target IC₅₀: 650 nM against COX-2 from human monocytes; 4.3 µM against COX-2 in whole blood
Primary Target
COX-2 from human monocytes
Product does not compete with ATP.
Reversible: no

Toxicity: Standard Handling (A)

Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Palomer, A., et al. 2002. J. Med. Chem.45, 1402.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

100

≥97% (HPLC)

solid

Calbiochem^®

OK to freeze
protect from light

white

methanol: 1 mg/mL
DMSO: 100 mg/mL

ambient

−20℃

5 mg in Plastic ampoule
Packaged under inert gas

11 - Combustible Solids

WGK 1