Diacylglycerol Kinase Inhibitor II-CAS 120166-69-0-Calbiochem

C₂₈H₂₅F₂N₃OS

489.58

MFCD00069258

Inhibits diacylglycerol kinase in isolated platelet membranes (IC₅₀ = 300 nM) and in intact platelets (IC₅₀ = 120 nM) by binding to the catalytic domain. A more potent analog of diacylglycerol kinase inhibitor I (Cat. No. 266785).
Inhibitor useful for elucidating roles of protein kinase C. Inhibits diacylglycerol (DAG) kinase in isolated platelet membranes (IC₅₀ = 300 nM) and in intact platelets (IC₅₀ = 120 nM). A more potent analog of DAG kinase inhibitor I.

Product does not compete with ATP.
Reversible: no
Target IC₅₀: 300 nM and 120 nM against diacylglycerol kinase in isolated platelet membranes and in intact platelets, respectively
Cell permeable: no

Toxicity: Irritant (B)

Following reconstitution, aliquot, flush with an inert gas and freeze at -20°C. Stock solutions are stable for up to 6 months at -20°C.

Jiang, Y., et al. 2000. Biochem. Pharmacol. 59, 763.
Jones, D.R., et al. 1999. J. Biol. Chem.274, 16846.
Rodriguez-Linares, B., et al. 1991. Biochem. Pharmacol. 41, 835.
de Chaffoy de Courcelles, D., et al. 1989. J. Biol. Chem.264, 3274.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

100

≥98% (HPLC)

solid

Calbiochem^®

OK to freeze

white

DMSO: 12.5 mg/mL

ambient

10-30℃

1S/C28H25F2N3OS/c29-22-9-5-19(6-10-22)26(20-7-11-23(30)12-8-20)21-13-15-32(16-14-21)17-18-33-27(34)24-3-1-2-4-25(24)31-28(33)35/h1-12H,13-18H2,(H,31,35)

ZCNBZFRECRPCKU-UHFFFAOYSA-N

5 mg in Glass bottle

11 - Combustible Solids

WGK 3