Furin Substrate, Fluorogenic-Calbiochem

C₃₇H₅₇N₁₃O₉

827.93

A fluorogenic substrate for furin, a mammalian homolog of the yeast Kex2 endoprotease (k_cat/K_m ~ 2 x 10⁴ s^-1M^-1).
A fluorogenic substrate for furin (k_cat/K_m ~2 X 10⁴ M^-1 s^-1), a mammalian homolog of the yeast Kex2 endoprotease. Also serves as a substrate for related protein, prohormone convertase 2 (PC2) (k_cat/K_m ~6 X 10³ M^-1 s^-1). Excitation max: ~360-380 nm; emission max: ~430-460 nm).

Primary Target
Fluorogenic substrate for furin
kcat/Km ~ 2 x 104 s-1M-1 for furin
Product does not compete with ATP.
Reversible: no
Cell permeable: no

Toxicity: Standard Handling (A)

Pyr-Arg-Thr-Lys-Arg-AMC

Supplied as a trifluoroacetate salt.

Following reconstitution, aliquot and freeze (-20°). Stock solutions are stable for up to 3 months at -20°C.

Lamango, N.S., et al. 1996. Arch. Biochem. Biophys.330, 238.
Hatsuzawa, K., et al. 1992. J. Biol. Chem. 267, 16094.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

100

≥95% (HPLC)

solid

Calbiochem^®

OK to freeze
desiccated (hygroscopic)
protect from light

white

water: 10 mg/mL
DMSO: soluble

λ_ex 360 - 380  nm
λ_em 430-460 nm

ambient

−20℃

5 mg in Plastic ampoule

11 - Combustible Solids

WGK 1