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InSolution Casein Kinase II Inhibitor I-Calbiochem
| 产品编号： | 4083870 |
| 规格： | The InSolution |
| 包装规格： | 5 MG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
基本信息
| Empirical Formula【经验(实验)分子式】 | C6HBr4N3 |
| Molecular weight | 434.71 |
| General description【一般描述】 | A cell-permeable, highly selective, ATP/GTP-competitive casein kinase II (CKII) inhibitor (IC50 = 900 nM and 1.6 µM for rat liver and human recombinant CKII, respectively) and DYRK (IC50<1 µM for DYRK1a). Specificity for CKII has been reported following the screening of 33 kinases, including PKA, Akt, PKC, MKK1, ERK2, p38, JNK, Lck, Lyn, and Syk. Also reported to inhibit NS3-associated viral helicase activity in hepatitis C virus (HCV) (IC50 = 20 and 60 µM using DNA and RNA substrates, respectively) and West Nile virus (WNV) (IC50 = 1.7 µM and 900 nM using DNA and RNA substrates, respectively). |
| Biochem/physiol Actions【生化/生理作用】 | Reversible: yes Cell permeable: yes Primary Target CK2 rat liver, human recombinant Product competes with ATP. Target IC50: 900 nM and 1.6 µM, using rat liver and human recombinant CK2, respectively |
| Warning【警告】 | Toxicity: Carcinogenic / Teratogenic (D) |
| Physical form【外形】 | A 10 mM (5 mg/1.15 ml) solution of Casein Kinase II Inhibitor I (Cat. No. 218697) in DMSO. |
| Reconstitution【重悬】 | Following initial use, aliquot and refrigerate (4°C). |
| Analysis Note【分析说明】 | Single spot by TLC |
| Other Notes【其他说明】 | Borowski, P., et al. 2003. Eur. J. Biochem.270, 1645. Zien, P., et al. 2003. Biochem. Biophys. Res. Commun.306, 129. Sarno, S., et al. 2003. Biochem. J.374, 639. Sarno, S., et al. 2001. FEBS Lett.496, 44. Szyszka, R., et al. 1995. Biochem. Biophys. Res. Commun.208, 418." |
| Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
| Quality Level【质量水平】 | 100 |
| form【形式】 | liquid |
| manufacturer/tradename | Calbiochem® |
| storage condition【储存条件】 | OK to freeze desiccated (hygroscopic) protect from light |
| shipped in【运输】 | wet ice |
| storage temp.【储存温度】 | 2-8℃ |
| packaging【包装】 | 5 mg in Plastic ampoule Packaged under inert gas |
安全信息
| Storage Class Code【储存分类代码】 | 10 - Combustible liquids |
| WGK | WGK 2 |
| Flash Point(F)【闪点(F)】 | 188.6 °F - (Dimethylsulfoxide) |
| Flash Point(C)【闪点(C)】 | 87 ℃ - (Dimethylsulfoxide) |
