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InSolution eIF-2α Inhibitor, Salubrinal-CAS 304475-63-6-Calbiochem
| 产品编号： | 4083872 |
| 规格： | The InSolution |
| CAS NO： | 304475-63-6 |
| 包装规格： | 5 MG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品价格查看更多规格...
| 产品编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
| 4083872 | 5 MG | 3350 |
产品别名
304475-63-6
InSolution eIF-2α Inhibitor, Salubrinal-CAS 304475-63-6-Calbiochem
N-(2,2,2-Tichloro-1-(3-quinolin-8-ylthioureido)ethyl)cinnamamide
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C21H17Cl3N4OS |
| Molecular weight | 479.81 |
| MDL number | MFCD00548612 |
| General description【一般描述】 | A cell-permeable and selective inhibitor of the phosphatase complexes that dephosphorylate eukaryotic translation initiation factor 2 subunit α (eIF-2α). Shown to offer protection against ER stress-induced apoptosis (EC50 ~15 µM in PC12 cells stimulated with 750 ng/ml of Tunicamycin (Cat. No. 654380). Prevents HSV replication both in Vero cells (IC50 ~3 µM for reducing plaque formation) in vitro and in a mouse cornea infection model in vivo. The solid form of this compound (Cat. No. 324895) is also available. |
| Biochem/physiol Actions【生化/生理作用】 | Cell permeable: yes Primary Target eIF-2α |
| Warning【警告】 | Toxicity: Irritant (B) |
| Physical form【外形】 | A 50 mM (5 mg/208 µL) solution of eIF-2α Inhibitor, Salubrinal (Cat. No. 324895) in DMSO. |
| Reconstitution【重悬】 | Following initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 6 months at -70°C. |
| Other Notes【其他说明】 | Boyce, M., et al. 2005. Science307, 935. |
| Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥95% (HPLC) |
| form【形式】 | liquid |
| manufacturer/tradename | Calbiochem® |
| storage condition【储存条件】 | OK to freeze avoid repeated freeze/thaw cycles desiccated (hygroscopic) protect from light |
| shipped in【运输】 | dry ice |
| storage temp.【储存温度】 | −70℃ |
| SMILES string | S=C(NC(NC(/C=C/C1=CC=CC=C1)=O)C(Cl)(Cl)Cl)NC2=CC=CC3=C2N=CC=C3 |
| packaging【包装】 | 5 mg in Glass bottle Packaged under inert gas |
安全信息
| Storage Class Code【储存分类代码】 | 10 - Combustible liquids |
| WGK | WGK 1 |
| Flash Point(F)【闪点(F)】 | 188.6 °F - (refers to pure substance) |
| Flash Point(C)【闪点(C)】 | 87 ℃ - (refers to pure substance) |
