InSolution Purmorphamine-Calbiochem

100

≥98% (HPLC)

liquid

Calbiochem^®

OK to freeze
desiccated (hygroscopic)
protect from light

−20℃

5 mg in Plastic ampoule
Packaged under inert gas

Purmorphamine is a cell-permeable purine compound that induces osteoblast differentiation in C3H10T1/2 multipotent mesenchymal progenitor cells.
A cell-permeable purine compound that induces osteoblast differentiation in C3H10T1/2 multipotent mesenchymal progenitor cells (EC₅₀ = 1 µM) and in MC3T3-E1 lineage-committed preosteoblasts. Also shown to induce transdifferentiation in pre-adipocytes and myoblasts. Its effects are reported to be synergistic with bone morphogenetic protein-4 (BMP-4). Reported to induce osteogenesis by activation of the Hedgehog signaling pathway.

InSolution Purmorphamine, CAS 483367-10-8, is a provided as a 50 mM solution in DMSO. Induces osteoblast differentiation of multipotent mesenchymal progenitor cells C3H10T1/2 & lineage-committed preosteoblasts MC3T3-E1.

Toxicity: Irritant (B)

A 50 mM (5 mg/192 µl) solution of Purmorphamine (Cat. No. 540220) in DMSO.

Following initial thaw, aliquot and freeze (-20°C).

Wu, X., et al. 2004. Chem. Biol.11, 1229.
Wu, X., et al. 2002. J. Am. Chem. Soc.124, 14520.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

GHS08

Warning

H341

P201 - P202 - P280 - P308 + P313 - P405 - P501

Muta. 2

10 - Combustible liquids

WGK 2

188.6 °F

87 ℃