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InSolution TGF-β RI Kinase Inhibitor VI, SB431542-CAS 301836-41-9-Calbiochem
| 产品编号： | 4083880 |
| 规格： | The InSolution |
| CAS NO： | 301836-41-9 |
| 包装规格： | 5 MG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品价格查看更多规格...
| 产品编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
| 4083880 | 5 MG | 2150 |
产品别名
301836-41-9
InSolution TGF-β RI Kinase Inhibitor VI, SB431542-CAS 301836-41-9-Calbiochem
基本信息
| Empirical Formula【经验(实验)分子式】 | C22H16N4O3 · 2H2O |
| Molecular weight | 420.42 |
| General description【一般描述】 | A cell-permeable triarylimidazole compound that is shown to effectively inhibit cellular Smad2 phosphorylation (>90% inhibition by 10 µM inhibitor) upon vector-mediated expression of constitutively active ALK4, ALK5, or ALK7 in NIH 3T3 cells, while exhibiting little effect against Smad1 phosphorylation by other members of type I receptors for TGF-β in NIH 3T3 cultures expressing active ALK1, 2, 3, or 6. When tested directly in cell-free kinase assays, SB431542 is demonstrated to potently inhibit the activity of ALK4 and ALK5 (IC50 = 140 nM and 94 nM, respectively) with no or much reduced potency toward a panel of 24 other kinases (IC50 ≥10 µM in the presence of 10 µM ATP), including ALK2 and ALK6. Reported to improve the efficiency of 4-TF-induced human iPSCs generation from fibroblast cultures by >200-fold when used together with PD0325901 (Cat. No. 444966) and Thiazovivin (Cat. No. 420220). |
| Warning【警告】 | Toxicity: Irritant (B) |
| Physical form【外形】 | A 100 mM (5 mg/119 µl) solution of SB431542 (Cat. No. 616461) in DMSO. |
| Reconstitution【重悬】 | Following initial thaw, aliquot and freeze (-20°C). |
| Other Notes【其他说明】 | Ikushima, H., et al. 2009. Cell Stem Cell5, 504. Lin, T., et al. 2009. Nat. Methods6, 805. Maherali, N. and Hochedlinger, K., 2009. Curr. Biol.19, 1718. Callahan, J.F., et al. 2002. J. Med. Chem.45, 999. Inman, G.J., et al. 2002. Mol. Pharmacol.62, 65. Laping, N.J., et al. 2002. Mol. Pharmacol.62, 58. |
| Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥97% (HPLC) |
| form【形式】 | liquid |
| manufacturer/tradename | Calbiochem® |
| storage condition【储存条件】 | OK to freeze desiccated (hygroscopic) protect from light |
| shipped in【运输】 | ambient |
| storage temp.【储存温度】 | −20℃ |
| packaging【包装】 | 5 mg in Glass bottle Packaged under inert gas |
安全信息
| Storage Class Code【储存分类代码】 | 10 - Combustible liquids |
| WGK | WGK 1 |
| Flash Point(F)【闪点(F)】 | 188.6 °F - (refers to pure substance) |
| Flash Point(C)【闪点(C)】 | 87 ℃ - (refers to pure substance) |
