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InSolutionBlebbistatin, Racemic-Calbiochem
| 产品编号： | 4083881 |
| 规格： | InSolution |
| 包装规格： | 5 MG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
基本信息
| Empirical Formula【经验(实验)分子式】 | C18H16N2O2 |
| Molecular weight | 292.33 |
| General description【一般描述】 | A cell-permeable compound that acts as a selective, potent, and reversible inhibitor of non-muscle myosin II. Inhibits the ATPase and gliding motility of human platelets (≤100 µM) without affecting myosin light chain kinase (MLCK) activity. Has been shown to block cell blebbing and to rapidly disrupt directed cell migration and cytokinesis in vertebrate cells. Does not disrupt mitosis or affect contractile ring assembly. |
| Biochem/physiol Actions【生化/生理作用】 | Cell permeable: yes Primary Target ATPase Product does not compete with ATP. Target IC50: <100 µM inhibiting the ATPase and gliding motility of human platelets Reversible: yes |
| Warning【警告】 | Toxicity: Harmful & Carcinogenic / Teratogenic (E) |
| Physical form【外形】 | A 50 mM (5 mg/342 µl) solution of (±)-Blebbistatin (Cat. No. 203390) in 90% DMSO. |
| Reconstitution【重悬】 | Following initial thaw, aliquot and freeze (-20°C). |
| Other Notes【其他说明】 | Shu, S., et al. 2005. Proc. Natl. Acad. Sci. USA102, 1472. Kovacs, M., et al. 2004. J. Biol. Chem.279, 35557. Straight, A.F., et al. 2003. Science299, 1743. Cheung, A., et al. 2001. Mol. Biol. Cell Suppl.12, 271a. |
| Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥97% (HPLC) |
| form【形式】 | liquid |
| manufacturer/tradename | Calbiochem® |
| storage condition【储存条件】 | OK to freeze desiccated (hygroscopic) protect from light |
| shipped in【运输】 | wet ice |
| storage temp.【储存温度】 | −20℃ |
| packaging【包装】 | 5 mg in Plastic ampoule Packaged under inert gas |
