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Interleukin-1β, Mouse, Recombinant, E. coli

产品编号:4083883
包装规格:5 μG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
40838835 μG7430
产品性质
Quality Level【质量水平】
100
Assay【测定】
≥97% (SDS-PAGE)
form【形式】
lyophilized
manufacturer/tradename
Calbiochem®
storage condition【储存条件】
OK to freeze
impurities【杂质】
≤1.0 EU/μg Endotoxin (EU/μg IL-1β)
shipped in【运输】
ambient
storage temp.【储存温度】
−70℃
packaging【包装】
5 μg in Plastic ampoule
基本信息
General description【一般描述】
Recombinant, mouse interleukin-1β expressed in E. coli. Suppresses apoptosis in rat ovarian follicles. Involved in inflammatory and immune responses and promotes wound healing.
Recombinant, mouse interleukin-1β expressed in E. coli. Suppresses apoptosis in rat ovarian follicles. Involved in inflammatory and immune responses and promotes wound healing. Interleukin-1 is a protein produced by stimulated macrophages and many other cell types. The following biological activities are attributed to IL-1: activation of T cells resulting in the production of IL-2 and expression of IL-2 receptors; initiation of Acute Phase Response by induction of hepatic protein synthesis; increased proteolysis of muscle proteins, amino acid mobilization, and caloric and oxygen utilization; induction of bone resorption; stimulation of fibroblast proliferation; induction of slow-wave sleep; fever production; induction of prostaglandin and leukotriene production; stimulation of thymocyte proliferation; induction of B cell proliferation and maturation and increased immunoglobulin synthesis; induction of collagenase and other proteinases in synovial fibroblasts and articular chrondrocytes, suggesting a role in pathological states such as arthritis; activation of neutrophils. 1 µg is equivalent to 1.1 x 106 WHO units.
Biochem/physiol Actions【生化/生理作用】
ED₅₀= 5-10 pg/ml as measured in a cell proliferation assay
Warning【警告】
Toxicity: Standard Handling (A)
Physical form【外形】
Lyophilized from sterile-filtered PBS, 50 µg BSA/µg IL-1β.
Reconstitution【重悬】
Reconstitute to a concentration of ≥10 µg/ml with sterile PBS containing ≥0.1% HSA or BSA.
Following reconstitution, aliquot and freeze (-70°C) for long term storage or refrigerate (4°C) for short-term storage. Avoid freeze/thaw cycles of solutions. Stock solutions are stable for up to 1 month at 4°C or for up to 3 months at -70°C.
Other Notes【其他说明】
Chun, S.Y., et al. 1995. Endocrinology136, 3120.
Weidmann, B., et al. 1994. Nature370, 434.
Dinarello, C.A., and Wolff, S.M. 1993. N. Engl. J. Med.328, 106.
Legal Information【法律信息】
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
安全信息
Storage Class Code【储存分类代码】
11 - Combustible Solids
WGK
WGK 1
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