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Necrostatin-1-CAS 4311-88-0-Calbiochem
产品价格查看更多规格...
| 产品编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
| 4083917 | 5 MG | 2010 |
产品别名
4311-88-0
Necrostatin-1-CAS 4311-88-0-Calbiochem
Nec-1, Necrosome Inhibitor I, 5-(Indol-3-ylmethyl)-(2-thio-3-methyl)hydantoin, Necrosis Inhibitor II, Methyl-thiohydantoin-tryptophan, MTH-Trp, Receptor-Interacting Protein 1 Inhibitor I, RIPK 1 Inhibitor I, Nec1, RIP1 Inhibitor I
基本信息
| Empirical Formula【经验(实验)分子式】 | C13H13N3OS |
| Molecular weight | 259.33 |
| MDL number | MFCD00056916 |
| NACRES | NA.77 |
| General description【一般描述】 | A cell-permeable, potent, and selective blocker of necroptosis (EC50 = 494 nM in FADD-deficient Jurkat cells treated with TNF-α), a nonapoptotic necrotic cell death pathway mediated by death-domain receptors (DRs) that offers neuroprotection in a murine model of ischemic brain injury. Exhibits no effect on DR-induced apoptosis. Also acts as a selective and ATP-competitive inhibitor of RIP1 kinase with negligible effect of RIP2 kinase activity. Nec-1 target appears to be a critical common necroptotic step upstream of execution events and downstream of DRs. Inactive control, Nec-1i, is also available (Cat. No. 480066). Also available as a 25 mM solution in DMSO (Cat. No. 505224). A cell-permeable, potent, and selective blocker of necroptosis (EC50 = 494 nM in FADD-deficient Jurkat cells treated with TNF-α), a nonapoptotic necrotic cell death pathway mediated by death-domain receptors (DRs) that offers neuroprotection in a murine model of ischemic brain injury. Exhibits no effect on DR-induced apoptosis. Also acts as a selective and ATP-competitive inhibitor of RIP1 kinase with negligible effect of RIP2 kinase activity. Nec-1 target appears to be a critical common necroptotic step upstream of execution events and downstream of DRs. Inactive control, Nec-1i, is also available (Cat. No. 480066). |
| Biochem/physiol Actions【生化/生理作用】 | Cell permeable: yes Primary Target Blocker of necroptosis Reversible: no Product competes with ATP. EC50 = 494 nM in blocking necrosis in FADD-deficient Jurkat cells treated with TNF-α |
| Warning【警告】 | Toxicity: Standard Handling (A) |
| Reconstitution【重悬】 | Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. |
| Other Notes【其他说明】 | Degterev, A., et al. 2013. Nat. Chem. Biol.9, 192. Degterev, A., et al. 2012. Cell Death Differ.20, 366. Christofferson, D.E., et al. 2012. Cell Death Dis.3, e320. Takahashi, N., et al. 2012. Cell Death Dis.3, e437. Degterev, A., et al. 2008. Nat. Chem. Biol.4, 313. Degterev, A., et al. 2005. Nat. Chem. Biol.1, 112. Muller, A.J., et al. 2005. Nat. Med.11, 312. Teng, X., et al. 2005. Bioorg. Med. Chem. Lett.15, 5039. |
| Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥95% (HPLC) |
| form【形式】 | crystalline solid |
| manufacturer/tradename | Calbiochem® |
| storage condition【储存条件】 | OK to freeze protect from light |
| color【颜色】 | yellow |
| solubility【溶解性】 | DMSO: 10 mg/mL methanol: 5 mg/mL |
| shipped in【运输】 | ambient |
| storage temp.【储存温度】 | 2-8℃ |
| InChI | 1S/C13H13N3OS/c1-16-12(17)11(15-13(16)18)6-8-7-14-10-5-3-2-4-9(8)10/h2-5,7,11,14H,6H2,1H3,(H,15,18) |
| InChI key | TXUWMXQFNYDOEZ-UHFFFAOYSA-N |
| packaging【包装】 | 5 mg in Plastic ampoule Packaged under inert gas |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
