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PTP1B Inhibitor-CAS 765317-72-4-Calbiochem
| 产品编号： | 4083947 |
| 规格： | PTP1B Inhibitor, CAS 765317-72-4, is a cell-permeable, selective, reversible and non-competitive allosteric inhibitor of PTP1B (IC50 = 4 μM and 8 μM for PTP1B403 and PTP1B298, respectively). |
| CAS NO： | 765317-72-4 |
| 包装规格： | 5 MG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品价格查看更多规格...
| 产品编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
| 4083947 | 5 MG | 3730 |
产品别名
765317-72-4
PTP1B Inhibitor-CAS 765317-72-4-Calbiochem
3-(3,5-Dibromo-4-hydroxy-benzoyl)-2-ethyl-benzofuran-6-sulfonicacid-(4-(thiazol-2-ylsulfamyl)-phenyl)-amide, PTP Inhibitor XXII
基本信息
| Empirical Formula【经验(实验)分子式】 | C26H19Br2N3O7S3 |
| Molecular weight | 741.45 |
| General description【一般描述】 | A cell-permeable, selective, reversible, and non-competitive allosteric inhibitor of PTP1B (IC50 = 4 µM and 8 µM for PTP1B403 and PTP1B298, respectively). Binds to a novel site away from the catalytic pocket and inhibits PTP1B activity by preventing closure of the WPD loop. Also available in InSolution |
| Biochem/physiol Actions【生化/生理作用】 | Cell permeable: yes Target IC50: 4 µM and 8 µM for PTP1B403 and PTP1B298, respectively Product does not compete with ATP. Primary Target PTP1B403 Reversible: yes |
| Warning【警告】 | Toxicity: Standard Handling (A) |
| Reconstitution【重悬】 | Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C. |
| Other Notes【其他说明】 | Wiesmann, C., et al. 2004. Nat. Struct. Mol. Biol.11, 730. |
| Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥95% (HPLC) |
| form【形式】 | solid |
| manufacturer/tradename | Calbiochem® |
| storage condition【储存条件】 | OK to freeze protect from light |
| color【颜色】 | white |
| solubility【溶解性】 | DMSO: 100 mg/mL ethanol: 5 mg/mL |
| shipped in【运输】 | wet ice |
| storage temp.【储存温度】 | −20℃ |
| packaging【包装】 | 5 mg in Plastic ampoule Packaged under inert gas |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 2 |
