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Sulindac Sulfide-CAS 32004-67-4-Calbiochem
| 产品编号： | 4083971 |
| 规格： | A cell-permeable, active metabolite of Sulindac. |
| CAS NO： | 32004-67-4 |
| 包装规格： | 5 MG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品价格查看更多规格...
| 产品编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
| 4083971 | 5 MG | 1710 |
产品别名
32004-67-4
Sulindac Sulfide-CAS 32004-67-4-Calbiochem
(Z)-5-Fluoro-2-methyl-1-[ p-(methylthio)benzylidene]indene-3-acetic Acid
基本信息
| Empirical Formula【经验(实验)分子式】 | C20H17FO2S |
| Molecular weight | 340.41 |
| MDL number | MFCD00869764 |
| General description【一般描述】 | An active metabolite of the non-steroidal anti-inflammatory drug Sulindac (Cat. No. 574100). Inhibits Ras signaling. Strongly inhibits Ras-induced malignant transformation and Ras/Raf-dependent transactivation. Also decreases the Ras-induced activation of c-Raf-1 kinase. Inhibits cell growth and induces apoptosis in a time-and dose-dependent manner. Selectively inhibits prostaglandin H synthase-1 (PGHS-1; COX-1; ID50 = 0.5 µM) relative to prostaglandin H synthase-2 (PGHS-2; COX-2; ID50 = 14 µM). Reduces Aβ42 production independently of COX inhibition. A cell-permeable, active metabolite of Sulindac (Cat. No. 574100). Strongly inhibits Ras-induced malignant transformation and Ras/Raf-dependent transactivation. Also decreases the Ras-induced activation of c-Raf-1 kinase. Inhibits growth and induces apoptosis in prostate cancer cell lines. Selectively inhibits COX-1 (ID50 = 500 nM) compared to prostaglandin H synthase-2 (PGHS-2; COX-2; ID50 = 14 µM). Preferentially inhibits the secretion of Aβ42 in CHO cells stably transfected with both APP75, and the PS1 mutant M146L. |
| Biochem/physiol Actions【生化/生理作用】 | Cell permeable: yes ID50 = 500 nM against COX-1 Product does not compete with ATP. Reversible: no |
| Warning【警告】 | Toxicity: Harmful & Carcinogenic / Teratogenic (E) |
| Other Notes【其他说明】 | Weggen, S., et al. 2001. Nature414, 212. Lim, J.T., et al. 1999. Biochem. Pharmacol. 58, 1097. Herrmann, C., et al. 1998. Oncogene 17, 1769. Picariello, L., et al. 1998. Eur. J. Pharmacol. 360, 105. Arber, N., et al. 1997. Gastroenterology 113, 1892. Meade, E.A., et al. 1993. J. Biol. Chem. 268, 6610. |
| Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (TLC) |
| form【形式】 | solid |
| manufacturer/tradename | Calbiochem® |
| storage condition【储存条件】 | OK to freeze |
| color【颜色】 | yellow-orange |
| solubility【溶解性】 | DMSO: 25 mg/mL ethanol: 5 mg/mL |
| shipped in【运输】 | ambient |
| storage temp.【储存温度】 | 10-30℃ |
| InChI | 1S/C20H17FO2S/c1-12-17(9-13-3-6-15(24-2)7-4-13)16-8-5-14(21)10-19(16)18(12)11-20(22)23/h3-10H,11H2,1-2H3,(H,22,23)/b17-9+ |
| InChI key | LFWHFZJPXXOYNR-RQZCQDPDSA-N |
| packaging【包装】 | 5 mg in Plastic ampoule |
安全信息
| Pictograms【象形图】 | GHS07,GHS08 |
| Signal word【警示用语：】 | Danger |
| Hazard Statements | H302 - H317 - H334 - H361 |
| Precautionary Statements | P201 - P280 - P301 + P312 - P302 + P352 - P304 + P340 + P312 - P308 + P313 |
| Hazard Classifications【危险分类】 | Acute Tox. 4 Oral - Repr. 2 - Resp. Sens. 1 - Skin Sens. 1 |
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
