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Wnt Pathway Inhibitor XI, CCT036477-CAS 305372-78-5-Calbiochem
| 产品编号： | 4083977 |
| 规格： | The Wnt Pathway Inhibitor XI, CCT036477, also referenced under CAS 305372-78-5, controls the biological activity of Wnt Pathway. This small molecule/inhibitor is primarily used for Cancer applications. |
| CAS NO： | 305372-78-5 |
| 包装规格： | 5 MG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品价格查看更多规格...
| 产品编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
| 4083977 | 5 MG | 2360 |
产品别名
305372-78-5
Wnt Pathway Inhibitor XI, CCT036477-CAS 305372-78-5-Calbiochem
CCT036477, CRT Inhibitor VI, β-Catenin/Tcf Inhibitor VI
基本信息
| Empirical Formula【经验(实验)分子式】 | C21H18ClN3 |
| Molecular weight | 347.84 |
| MDL number | MFCD01831143 |
| General description【一般描述】 | A cell-permeable indole derivative that acts as an inhibitor of Wnt signaling and exhibits an inhibitory effect in a reporter cell line (IC50 = 4.6 µM) and demonstrates growth inhibition in multiple cancer cell lines, not by altering β-catenin accumulation but by blocking transcription at the β-catenin level. Displays reduced expression of Wnt target genes in myc and survivin-luciferase reporter assays, and exhibits in vivo activity by blocking the development of zebrafish at 20 µM and Xenopus embryos at 75 µM. |
| Warning【警告】 | Toxicity: Standard Handling (A) |
| Reconstitution【重悬】 | Following recontitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. |
| Other Notes【其他说明】 | Ewan, K., et al. 2010. Cancer Res.70, 5963. |
| Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥95% (1H-NMR) |
| form【形式】 | solid |
| manufacturer/tradename | Calbiochem® |
| storage condition【储存条件】 | OK to freeze protect from light |
| color【颜色】 | off-white |
| solubility【溶解性】 | DMSO: 50 mg/mL |
| shipped in【运输】 | ambient |
| storage temp.【储存温度】 | 2-8℃ |
| packaging【包装】 | 5 mg in Glass bottle Packaged under inert gas |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 2 |
