(Z-LL)₂ Ketone-Calbiochem

C₄₃H₆₄N₆O₉

809.00

A novel cysteine protease inhibitor that specifically and efficiently inhibits processing of the p-Prl signal peptide (IC₅₀ ~50 nM) without affecting the activities of signal peptidases and other proteases such as lysosomal cathepsins and proteasomes. (Z-LL)₂ ketone does not cause any modification of the proteasomal active site even at 100 µM levels; hence it does not block the action of the multicatalytic proteasome complex.
A novel cysteine protease inhibitor that specifically and efficiently inhibits processing of the p-Prl signal peptide (IC₅₀ = ~ 50 nM) without affecting the activities of signal peptidases and other proteases such as lysosomal cathepsins and proteasomes.

Product does not compete with ATP.
Target IC₅₀: ~ 50 nM inhibiting the processing of the p-Prl signal peptide
Reversible: no
Cell permeable: no
Primary Target
Processing of the p-Prl signal peptide

Toxicity: Standard Handling (A)

Z-Leu-Leu-NH-CH₂-CO-CH₂-NH-Leu-Leu-Z

single spot by TLC

Weihofen, A., et al. 2002. Science296, 2215.
Weihofen, A., et al. 2000. J. Biol. Chem. 275, 30951.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

100

lyophilized solid

Calbiochem^®

OK to freeze

off-white

DMSO: 1 mg/mL

ambient

−20℃

5 mg in Plastic ampoule
Packaged under inert gas

11 - Combustible Solids

WGK 1