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4-Cyano-3-methylisoquinoline
| 产品编号： | 4083982 |
| 规格： | A potent, cell-permeable, reversible, and specific inhibitor of protein kinase A (IC50 = 30 nM). |
| CAS NO： | 161468-32-2 |
| 包装规格： | 5 MG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
161468-32-2
4-Cyano-3-methylisoquinoline
PKA Inhibitor XI
基本信息
| Empirical Formula【经验(实验)分子式】 | C11H8N2 |
| Molecular weight | 168.19 |
| General description【一般描述】 | A potent, cell-permeable, specific inhibitor of protein kinase A (PKA; IC50 = 30 nM). Inhibition is competitive with respect to ATP. Shows only weak inhibitory activities against Ca2+-dependent protein kinase (CDPK), MLCK, PKC, and cyclic nucleotide-binding phosphatase (Pase). A potent, cell-permeable, reversible, and specific inhibitor of protein kinase A (IC50 = 30 nM). Inhibition is competitive with respect to ATP. Shows only weak inhibitory activities against Ca2+-dependent protein kinase (CDPK), MLCK, PKC, and cyclic nucleotide-binding phosphatase. |
| Biochem/physiol Actions【生化/生理作用】 | Cell permeable: yes Target IC50: 30 nM against protein kinase A Product competes with ATP. Reversible: yes Primary Target PKA |
| Warning【警告】 | Toxicity: Standard Handling (A) |
| Reconstitution【重悬】 | Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C. |
| Other Notes【其他说明】 | Lu, Z.X., et al. 1996. Biol. Chem. Hoppe Seyler 377, 373. |
| Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥95% (HPLC) |
| form【形式】 | solid |
| manufacturer/tradename | Calbiochem® |
| storage condition【储存条件】 | OK to freeze |
| color【颜色】 | white |
| solubility【溶解性】 | DMSO: 50 mg/mL |
| shipped in【运输】 | ambient |
| storage temp.【储存温度】 | 2-8℃ |
| packaging【包装】 | 5 mg in Glass bottle Packaged under inert gas |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 1 |
