您的位置：首页 > 产品中心 > AMPK 激活剂 V，氨苯砜-Calbiochem
AMPK 激活剂 V，氨苯砜-Calbiochem
AMPK Activator V, Ampkinone-Calbiochem
| 产品编号： | 4083995 |
| 规格： | The AMPK Activator V, Ampkinone modulates the biological activity of AMPK. This small molecule/inhibitor is primarily used for Biochemicals applications. |
| 包装规格： | 5 MG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
AMPK 激活剂 V，氨苯砜-Calbiochem
AMPK Activator V, Ampkinone-Calbiochem
AKN, AMPK Signaling Activator V
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C31H23NO6 |
| Molecular weight | 505.52 |
| MDL number | MFCD28143482 |
| General description【一般描述】 | A cell-permeable benzopyran compound that stimulates both LKB1 and CaMKK-mediated AMPK activity indirectly with no noticeable effect on purified AMPK, cellular AMP/ATP ratio, PI 3-K/Akt signaling and respiratory chain, and displays antidiabetic and antiobesity properties. Shown to induce phosphorylation of AMPK-Thr172 and ACC-Ser79 in L6 cells (EC50 = 4.3 µM), C2C12 myocytes, 3T3-L1 preadipocytes and HepG2 hepatic cells, and enhance glucose uptake and insulin sensitivity in high fat-diet-induced obesity mouse model (10 mg/kg, s.c.) with the lowering of cholesterol and nonesterified fatty acids. |
| Warning【警告】 | Toxicity: Regulatory Review (Z) |
| Reconstitution【重悬】 | Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C. |
| Other Notes【其他说明】 | Oh, S., et al. 2010. J. Med. Chem.53, 7405. |
| Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| manufacturer/tradename | Calbiochem® |
| storage condition【储存条件】 | OK to freeze protect from light |
| color【颜色】 | yellow |
| solubility【溶解性】 | DMSO: 25 mg/mL |
| shipped in【运输】 | wet ice |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | OC1=C(OC)C=CC2=C1OC(C)(C)C3=C2C=CC4=C3C(N(C5=CC=C(C(C6=CC=CC=C6)=O)C=C5)C4=O)=O |
| packaging【包装】 | 5 mg in Glass bottle Packaged under inert gas |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 2 |
