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Butein-CAS 487-52-5-Calbiochem
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| 产品编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
| 4084004 | 5 MG | 3730 |
产品别名
487-52-5
Butein-CAS 487-52-5-Calbiochem
2',4',3,4-Tetrahydroxychalcone
基本信息
| Empirical Formula【经验(实验)分子式】 | C15H12O5 |
| Molecular weight | 272.25 |
| MDL number | MFCD00017300 |
| General description【一般描述】 | A cell-permeable, reversible, substrate competitive, plant polyphenol that acts as a specific protein tyrosine kinase inhibitor. Potently inhibits the tyrosine kinase activity of the EGF receptor (IC50 = 65 µM) and p60c-src (IC50 = 65 µM). The inhibition is competitive with respect to ATP and non-competitive with respect to the substrate. Butein is also a potent antioxidant and anti-inflammatory agent. Has been shown to inhibit glutathione reductase and rat liver glutathione-S-transferase (IC50 = 9 µM). Reported to activate sirtuins and promote the survival of eukaryotic cells. A cell-permeable, reversible, substrate competitive, plant polyphenol that acts as a specific protein tyrosine kinase inhibitor. Potently inhibits the tyrosine kinase activity of the EGF receptor (IC50 = 65 µM) and p60c-src (IC50 = 65 µM) The inhibition is competitive with respect to ATP and non-competitive with respect to the substrate. Butein is also a potent antioxidant and anti-inflammatory agent. Has been shown to inhibit glutathione reductase (GSH-RD) and rat liver glutathione S-transferase (GST; IC50 = 9 µM). Reported to activate sirtuins and promote the survival of eukaryotic cells. |
| Biochem/physiol Actions【生化/生理作用】 | Cell permeable: yes Primary Target Tyrosine kinase activity of the EGF receptor Product competes with ATP. Reversible: yes Target IC50: 65 µM against tyrosine kinase activity of the EGF receptor |
| Warning【警告】 | Toxicity: Standard Handling (A) |
| Reconstitution【重悬】 | Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 weeks at -20°C. |
| Other Notes【其他说明】 | Howitz, K.T., et al. 2003. Nature425, 191. Chan, S.C., et al. 1998. Planta Med.64, 153. Yang, E.B., et al. 1998. Biochem. Biophys. Res. Commun. 245, 435. Zhang, K., et al. 1997. Biochem. Pharmacol. 54, 1047. Zhang, K., and Das, N.P. 1994. Biochem. Pharmacol. 47, 2063. |
| Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | solid |
| manufacturer/tradename | Calbiochem® |
| storage condition【储存条件】 | OK to freeze protect from light |
| color【颜色】 | yellow |
| solubility【溶解性】 | DMSO: 10 mg/mL methanol: soluble |
| shipped in【运输】 | ambient |
| storage temp.【储存温度】 | −20℃ |
| InChI | 1S/C15H12O5/c16-10-3-4-11(14(19)8-10)12(17)5-1-9-2-6-13(18)15(20)7-9/h1-8,16,18-20H/b5-1+ |
| InChI key | AYMYWHCQALZEGT-ORCRQEGFSA-N |
| packaging【包装】 | 5 mg in Plastic ampoule Packaged under inert gas |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
