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D609, Potassium Salt-CAS 83373-60-8-Calbiochem
| 产品编号： | 4084028 |
| 规格： | Selective inhibitor of phosphatidylcholine (PC)-specific phospholipase C (Ki = 5-10 μM). |
| CAS NO： | 83373-60-8 |
| 包装规格： | 5 MG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品价格查看更多规格...
| 产品编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
| 4084028 | 5 MG | 3730 |
产品别名
83373-60-8
D609, Potassium Salt-CAS 83373-60-8-Calbiochem
Tricyclodecan-9-yl-xanthogenate, K
基本信息
| Empirical Formula【经验(实验)分子式】 | C11H15OS2 · K |
| Molecular weight | 266.46 |
| MDL number | MFCD00171401 |
| General description【一般描述】 | Selective inhibitor of phosphatidylcholine (PC)-specific phospholipase C (Ki = 5-10 µM). Does not inhibit phosphatidylinositol-specific phospholipase C, phospholipase A, or phospholipase D. Also reported to inhibit LPS-stimulated ERK activation via its inhibitory effect on PLC. Inhibits angiogenesis by preventing the synthesis of basement membrane. Selective inhibitor of phosphatidylcholine-specific phospholipase C (PC-PLC) (Bacillus cereus, Ki = 5-10 µM). Does not inhibit (up to 50 µM) phosphatidylinositol-specific phospholipase C, phospholipase A2, and phospholipase D. Inhibitor of the sphingomyelinase activity. Also inhibits angiogenesis by preventing the synthesis of basement membrane (BM). |
| Biochem/physiol Actions【生化/生理作用】 | Primary Target pc-specificphopholipase c Product does not compete with ATP. Reversible: no Target Ki: 5-10 µM against phosphatidylcholine (PC)-specific phospholipase C Cell permeable: no |
| Warning【警告】 | Toxicity: Standard Handling (A) |
| Preparation Note【制备说明】 | tissue culture media should be at neutral pH, since product is active only at or slightly below pH 7.0. The compound is inactive at pH 7.4 and above, and it is hydrolyzed below pH 6.0. HEPES buffer should not be used as it renders D609 toxic. |
| Reconstitution【重悬】 | Material is very labile once in solution (1.5 day half-life in tissue culture medium). |
| Other Notes【其他说明】 | Monick, M.M., et al. 1999. J. Immunol. 162, 3005. Lozanski, G., et al. 1997. Biochem. J.328, 271. Maragoudakis, M.E., et al. 1993. Kidney Int. 43, 147. Doppler, C., et al. 1992. AIDS Res. Human Retroviruses8, 245. Schutze, S., et al. 1992. Cell71, 765. Sauer, G., et al. 1990. Cancer Lett.53, 97. Muller-Decker, K. 1989. Biochem. Biophys. Res. Commun.162, 198. Amtmann, E., et al. 1987. Biochem. Pharmacol.36, 1545. Sauer, G., et al. 1984. Proc. Natl. Acad. Sci. USA81, 3263. |
| Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| manufacturer/tradename | Calbiochem® |
| storage condition【储存条件】 | OK to freeze desiccated (hygroscopic) |
| color【颜色】 | off-white |
| solubility【溶解性】 | DMSO: 25 mg/mL water: 25 mg/mL |
| shipped in【运输】 | ambient |
| storage temp.【储存温度】 | 2-8℃ |
| InChI | 1S/C11H16OS2.K/c13-11(14)12-10-5-6-4-9(10)8-3-1-2-7(6)8;/h6-10H,1-5H2,(H,13,14); |
| InChI key | YFUFHKMDCZBHMY-UHFFFAOYSA-N |
| packaging【包装】 | 5 mg in Plastic ampoule |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
