γ-Secretase Inhibitor VI-CAS 287196-57-0-Calbiochem

C₁₆H₂₂FNO₂S

311.41

Cell permeable. Potently inhibits Aβ₄₂ production (IC₅₀ = 1.8 µM). Treatment of HEK293 cells with this inhibitor results in β-Secretase-cleaved APP fragments and secreted APPα, but no change in secreted APPsβ is observed indicating specific inhibition of γ-secretase.
A potent, cell-permeable inhibitor of γ-secretase that blocks the formation of Aβ₄₂ (IC₅₀ = 1.8 µM). Treatment of HEK293 cells with γ-secretase inhibitor VI results in an increase in β-secretase-cleaved, APP fragments and secreted APP_Sα, but no change in secreted APP_Sβ, indicating a specific inhibition of γ-secretase activity.

Cell permeable: yes
Target IC₅₀: 1.8 µM against Aβ42 production
Product does not compete with ATP.
Reversible: no
Primary Target
Aβ₄₂ production

Toxicity: Standard Handling (A)

Following reconstitution, aliquot and freeze at (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Rishton, G.M., et al. 2000. J. Med. Chem.43, 2297.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

100

≥98% (HPLC)

solid

Calbiochem^®

OK to freeze

white

DMSO: 200 mg/mL

ambient

−20℃

5 mg in Plastic ampoule

11 - Combustible Solids

WGK 1