Heat Shock Protein Inhibitor I-CAS 218924-25-5-Calbiochem

C₁₃H₁₁NO₄

245.23

A benzylidine lactam compound that inhibits the induction of heat shock proteins, including HSP70, HSP72, and HSP105. Blocks the development of thermotolerance in a dose-dependent manner, but does not affect the thermosensitivity of nontolerant cells. Reported to be less toxic and more effective than Quercetin (Cat. No. 551600), and, unlike quercetin, it does not affect the activities of PKA, PKC, and PTK.
A benzylidene lactam compound that blocks the induction of heat shock proteins HSP70, HSP72, and HSP105. Blocks the development of thermotolerance in a dose-dependent manner. Does not affect the thermosensitivity of nontolerant cells. Reported to be less toxic and more effective than Quercetin (Cat. No. 551600); and unlike Quercetin, it does not have an affect on the activities of PKA, PKC, or PTK.

Primary Target
Hsp70
Product does not compete with ATP.
Reversible: no
Cell permeable: no

Toxicity: Harmful (C)

Following reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 6 weeks at -20°C.

Koishi, M., et al. 2001. Clin. Cancer Res.7, 215.
Yokota, S., et al. 2000. Cancer Res.60, 2942.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

100

≥95% (HPLC)

powder

Calbiochem^®

OK to freeze
protect from light

white to light yellow

DMSO: 3 mg/mL
olive oil: soluble

ambient

−20℃

5 mg in Glass bottle
Packaged under inert gas

11 - Combustible Solids

WGK 3