InSolution Simvastatin, Sodium Salt-Calbiochem

C₂₅H₃₉O₆ · Na

458.56

Carboxylate form of Simvastatin (Cat. No. 567020) that is active in whole cells and in cell-free assays. A lipophilic 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor that blocks Ras function through inhibition of farnesylation. Also inhibits glucose-induced Ca²⁺-signaling and insulin secretion by blocking L-type Ca²⁺ channels in rat islet β-cells. Inhibits cell proliferation of human smooth muscle cells. The solid form of Simvastatin, Sodium Salt (Cat. No. 567021) is also available.
Carboxylate form of Simvastatin (Cat. No. 567020) that is active in whole cells and in cell-free assays. A lipophilic 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor that blocks Ras function through inhibition of farnesylation. Also inhibits glucose-induced Ca²⁺-signaling and insulin secretion by blocking L-type Ca²⁺ channels in rat islet β-cells. Inhibits cell proliferation of human smooth muscle cells. The solid form of this compound (Cat. No. 567021) is also available.

Cell permeable: yes
Reversible: yes

Toxicity: Irritant (B)

A 10 mM (5 mg/1.09 ml) solution of Simvastatin, Sodium Salt (Cat. No. 567021) in H₂O.

Following initial thaw, aliquot and freeze (-70°C).

Yada, T., et al. 1999. Br. J. Pharmacol.126, 1205.
Clutterbuck, R.D., et al. 1998. Br. J. Haematol.102, 522.
Yokoyama, K., et al. 1998. Mol. Biochem. Parasitol.94, 87.
Negre-Aminou, P., et al. 1997. Biochim. Biophys. Acta1345, 259.
Vrtovsnik, F., et al. 1997. Kidney Int.52, 1016.
Keyomarsi, K., et al. 1991. Cancer Res.51, 3602.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

100

≥95% (HPLC)

liquid

Calbiochem^®

OK to freeze
avoid repeated freeze/thaw cycles
protect from light

ambient

−70℃

5 mg in Glass bottle
Packaged under inert gas

12 - Non Combustible Liquids

WGK 2