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JAK3 Inhibitor I-CAS 202475-60-3-Calbiochem
| 产品编号： | 4084089 |
| 规格： | The JAK3 Inhibitor I, also referenced under CAS 202475-60-3, controls the biological activity of JAK3. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. |
| CAS NO： | 202475-60-3 |
| 包装规格： | 5 MG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品价格查看更多规格...
| 产品编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
| 4084089 | 5 MG | 3010 |
产品别名
202475-60-3
JAK3 Inhibitor I-CAS 202475-60-3-Calbiochem
4-(4'-Hydroxyphenyl)amino-6,7-dimethoxyquinazoline, WHI-P131
基本信息
| Empirical Formula【经验(实验)分子式】 | C16H15N3O3 |
| Molecular weight | 297.31 |
| General description【一般描述】 | A cell-permeable, reversible, potent, ATP-competitive, and specific inhibitor of JAK3 (Janus family kinase 3; IC50 = 78 µM). Has no effect on JAK1, JAK2, or Zap/Syk or Src tyrosine kinases. Acts as a potent inhibitor of glioblastoma cell adhesion and migration. Also reported to block thrombin-induced platelet aggregation. A cell-permeable, reversible, potent, ATP-competitive, and specific inhibitor of JAK3 (Janus family kinase 3) (IC50 = 78 µM). Has no effect on either JAK1, JAK2, Zap/Syk or Src kinases. Blocks thrombin-induced platelet aggregation. |
| Biochem/physiol Actions【生化/生理作用】 | Cell permeable: yes Primary Target Janus family kinase 3 Target IC50: 78 µM against Janus family kinase 3 Product competes with ATP. Reversible: yes |
| Warning【警告】 | Toxicity: Standard Handling (A) |
| Other Notes【其他说明】 | Tibbles, H.E., et al. 2001. J. Biol. Chem.276, 17815. Sudbeck, E.A., et al. 1999. Clin. Cancer Res.5, 1569. Goodman, P.A., et al. 1998. J. Biol. Chem. 273, 17742. Narla, R.K., et al. 1998. Clin. Cancer Res. 4, 2463. |
| Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥97% (HPLC) |
| form【形式】 | solid |
| manufacturer/tradename | Calbiochem® |
| storage condition【储存条件】 | OK to freeze protect from light |
| color【颜色】 | white to off-white |
| solubility【溶解性】 | DMSO: 50 mg/mL |
| shipped in【运输】 | ambient |
| storage temp.【储存温度】 | −20℃ |
| packaging【包装】 | 5 mg in Plastic ampoule Packaged under inert gas |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 1 |
