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JC-1-CAS 47729-63-5-Calbiochem
| 产品编号： | 4084092 |
| 规格： | A cationic, fluorescent, carbocyanine dye that can be used as a ratiometric indicator of mitochondrial potential δΨm in cells, tissues, and isolated mitochondria. |
| CAS NO： | 47729-63-5 |
| 包装规格： | 5 MG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
47729-63-5
JC-1-CAS 47729-63-5-Calbiochem
5,5',6,6'-Tetrachloro-1,1',3,3'-tetraethylbenzimidazolylcarbocyanine iodide
基本信息
| Empirical Formula【经验(实验)分子式】 | C25H27Cl4IN4 |
| Molecular weight | 652.23 |
| General description【一般描述】 | A cationic, fluorescent, carbocyanine dye that can be used as a ratiometric indicator of mitochondrial potential ΔΨm in cells, tissues, and isolated mitochondria. It labels mitochondria with high membrane potential orange and mitochondria with low membrane potential green. Mitochondrial depolarization is indicated by a decrease in the red/green fluorescence intensity ratio. Ideal for detection of collapse of ΔΨm induced by uncouplers of mitochondrial respiration. The potential-sensitive color shift is due to concentration-dependent formation of red fluorescent J-aggregates. JC-1 has also been used in a functional assay of multidrug-resistance cells and in apoptosis-related mitochondrial modifications. A cationic, fluorescent, carbocyanine dye that can be used as a ratiometric indicator of mitochondrial potential ΔΨm in cells, tissues, and isolated mitochondria. Mitochondrial depolarization is indicated by a decrease in the red/green fluorescence intensity ratio. The potential-sensitive color shift is due to concentration-dependent formation of red fluorescent J-aggregates. Ideal for detection of collapse of ΔΨm induced by uncouplers of mitochondrial respiration. JC-1 has also been used in a functional assay of multidrug-resistance cells and in apoptosis-related mitochondrial modifications. |
| Biochem/physiol Actions【生化/生理作用】 | Product does not compete with ATP. Reversible: no Cell permeable: no Primary Target Used as a ratiometric indicator of mitochondrial potential δΨm in cells, tissues, and isolated mitochondria |
| Warning【警告】 | Toxicity: Irritant (B) |
| Reconstitution【重悬】 | Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C. Do not reuse thawed samples. |
| Other Notes【其他说明】 | Mathur, A., et al. 2000. Cardiovasc. Res. 46, 126. Gravance, C.G., et al. 2000. Theriogenology53, 1691. Chanda, B., and Mathew, M.K. 1999. Biochim Biophys. Acta 1416, 92. Dedov, V.N., and Roufogalis, B.D. 1999. FEBS Lett. 456, 171. Polla, B.S., et al. 1996. Proc. Natl. Acad. Sci. USA 93, 6458. White, R.J., and Reynolds, I.J. 1996. J. Neurosci. 16, 5688. Ankacrona, M., et al. 1995. Neuron 15, 961. Reers, M., et al. 1995. Methods Enzymol. 260, 406. Cossarizza, A., et al. 1993. Biochem. Biophys. Res. Commun. 197, 40. |
| Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥95% (HPLC) |
| form【形式】 | solid |
| manufacturer/tradename | Calbiochem® |
| storage condition【储存条件】 | OK to freeze protect from light |
| color【颜色】 | red-orange |
| solubility【溶解性】 | DMSO: 5 mg/mL |
| shipped in【运输】 | ambient |
| storage temp.【储存温度】 | −20℃ |
| packaging【包装】 | 5 mg in Plastic ampoule Packaged under inert gas |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
