JNK3 Inhibitor XII, SR-3576-CAS 1164153-22-3-Calbiochem

C₂₇H₂₇N₅O₅

501.53

MFCD18632556

A cell-permeable pyrazolourea compound that acts as a potent, ATP binding pocket-targeting, and JNK3-selective inhibitor (IC₅₀ = 7 nM), inhibiting JNK1 only at much higher concentrations (IC₅₀ = 170 nM) and exhibiting little activity against p38 even at concentrations as high as 20 µM. Shown to inhibit streptozotocin- (Cat. No. 572201) induced c-jun phosphorylation in INS-1 rat β-pancreatic cells (IC₅₀ = 1.3 µM).
A cell-permeable pyrazolourea compound that acts as a potent, ATP binding pocket-targeting, and JNK3-selective inhibitor (IC₅₀ = 7 nM), inhibiting JNK1 only at much higher concentrations (IC₅₀ = 170 nM) and exhibiting little activity against p38 even at concentrations as high as 20 µM. Shown to inhibit streptozotocin- (Cat. No. 572201) induced c-jun phosphorylation in INS-1 rat β-pancreatic cells (IC₅₀ = 1.3 µM).

Toxicity: Standard Handling (A)

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Kamenecka, T., et al. 2009. J. Biol. Chem.284, 12853.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

100

≥95% (HPLC)

solid

Calbiochem^®

OK to freeze
protect from light

off-white

DMSO: 100 mg/mL

ambient

2-8℃

5 mg in Glass bottle
Packaged under inert gas

11 - Combustible Solids

WGK 3