Luteolin-CAS 491-70-3-Calbiochem

C₁₅H₁₀O₆

286.24

MFCD00017309

An antioxidant flavonoid and a free radical scavenger. Inhibits rat liver cytosolic glutathione S-transferase activity. Also shows cytotoxic effects on Raji lymphoma cells. Incubation of the non-tumor cell line C3H10T½CL8 with luteolin results in induction of p53 accumulation and apoptosis, with apoptosis occurring at the G₂/M phase of the cell cycle. Also shown to inhibit TPL2 kinase.
An antioxidant flavonoid and a free radical scavenger. Inhibits rat liver cytosolic glutathione S-transferase activity. Also shows cytotoxic effects on Raji lymphoma cells. Incubation of the non-tumor cell line C3H10T1/2CL8 with luteolin results in induction of p53 accumulation and apoptosis, with apoptosis occurring at the G₂/M phase of the cell cycle. Also shown to inhibit TPL2 kinase.

Primary Target
rat liver cytosolic glutathione S-transferase activity
Product does not compete with ATP.
Reversible: no
Cell permeable: no

Toxicity: Standard Handling (A)

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 weeks at -20°C.

Kim, J.E., et al. 2011. J. Pharmacol. Exp. Ther.in press.
Korkina, L.G., and Afanasev, I.B. 1997. Adv. Pharmacol.38, 151.
Plaumann, B., et al. 1996. Oncogene 13, 1605.
Ramanathan, R., et al. 1994. Free Radic. Biol. Med.16, 43.
Shimoi, L., et al. 1994. Carcinogenesis15, 2669.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

100

≥90% (HPLC)

solid

Calbiochem^®

OK to freeze
protect from light

yellow

aqueous base: 1.4 mg/mL
DMSO: 7 mg/mL
ethanol: soluble

ambient

2-8℃

1S/C15H10O6/c16-8-4-11(19)15-12(20)6-13(21-14(15)5-8)7-1-2-9(17)10(18)3-7/h1-6,16-19H

IQPNAANSBPBGFQ-UHFFFAOYSA-N

5 mg in Glass bottle
Packaged under inert gas

11 - Combustible Solids

WGK 3