MG-115-CAS 133407-86-0-Calbiochem

C₂₅H₃₉N₃O₅

461.59

Potent reversible proteasome inhibitor (K_i = 21 nM and 35 nM for 20S and 26S proteasome, respectively).
Potent reversible proteasome inhibitor (K_i = 21 nM and 35 nM for 20S and 26S proteasome, respectively). Specifically inhibits the chymotrypsin-like activity of the proteasome and induces apoptosis in Rat-1 and PC12 cells.

Product does not compete with ATP.
Target K_i: 21 nM and 35 nM for 20S and 26S proteasome, respectively
Cell permeable: no
Reversible: yes
Primary Target
20S proteasome

Toxicity: Standard Handling (A)

Z-Leu-Leu-Nva-CHO

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Lopes, U.G., et al. 1997. J. Biol. Chem. 272, 12893.
Lee, D.H., and Goldberg, A.L. 1996. J. Biol. Chem.271, 27280.
Palombella, V.J., et al. 1994. Cell 78, 773. Rock, K.L., et al. 1994. Cell 78, 761.
Vinitsky, A., et al. 1992. Biochemistry 31, 9421.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

100

≥90% (HPLC)

solid

Calbiochem^®

OK to freeze
protect from light

white

DMSO: 50 mg/mL

ambient

−20℃

5 mg in Plastic ampoule

11 - Combustible Solids

WGK 3