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MK-886-CAS 118414-82-7-Calbiochem
| 产品编号： | 4084109 |
| 规格： | A cell-permeable, orally active NSAID that blocks cellular Cox pathway PGE2 production by inhibiting COX-1 and mPGES-1, but not COX-2, activity, as well as suppresses cellular 5-LO pathway activation by inhibiting FLAP, rather than 5-LO, activity. |
| CAS NO： | 118414-82-7 |
| 包装规格： | 5 MG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
118414-82-7
MK-886-CAS 118414-82-7-Calbiochem
3-[1-( p-Chlorobenzyl)-5-(isopropyl)-3- t-butylthioindol-2-yl]-2,2-dimethylpropanoic Acid, Na, COX-1 Inhibitor III, FLAP Inhibitor I, MK886, mPGES-1 Inhibitor I
基本信息
| Empirical Formula【经验(实验)分子式】 | C27H33ClNO2S · Na |
| Molecular weight | 494.06 |
| General description【一般描述】 | A cell-permeable, orally active NSAID (nonsteroidal antiinflammatory drug) that blocks cellular Cox pathway PGE2 (prostaglandin E2) production by inhibiting COX-1 and mPGES-1 (microsomal PGE2 synthase-1), but not COX-2, activity (IC50 = 8, 2, and 58 M, respectively), as well as suppresses cellular 5-LO (5-Lypoxygenase; Cat. No. 437996) pathway activation by inhibiting FLAP (5-LO-activating protein), rather than 5-LO, activity (<10% by 1 M MK-886). Unlike NSAIDs (nonsteroidal antiinflammatory drugs) that target only COX pathway, MK-886 does not cause gastrointestinal damages when applied in vivo. |
| Biochem/physiol Actions【生化/生理作用】 | Cell permeable: yes Primary Target leukotreine biosybthesis Product does not compete with ATP. Reversible: no |
| Warning【警告】 | Toxicity: Standard Handling (A) |
| Other Notes【其他说明】 | Koeberle, A., et al. 2009. Eur. J. Pharmacol.608, 84. Koeberle, A., et al. 2008. J. Pharmacol. Exp. Ther.326, 975. Fisher, L., et al. 2007. Br. J. Pharmacol.152, 471. Ford-Hutchinson, A.W., et al. 1993. Can. J. Physiol. Pharmacol. 71, 806. Ford-Hutchinson, A.W. 1991. Trends Pharmacol.12, 68. Dixon, R.A., et al. 1990. Nature 343, 282. Rouzer, C.A., et al. 1990. J. Biol. Chem.265, 1436. |
| Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥99% (TLC) |
| form【形式】 | solid |
| potency【效能】 | 102 nM IC50 |
| manufacturer/tradename | Calbiochem® |
| storage condition【储存条件】 | OK to freeze |
| color【颜色】 | white |
| solubility【溶解性】 | DMSO: 25 mg/mL ethanol: 25 mg/mL |
| shipped in【运输】 | ambient |
| storage temp.【储存温度】 | 10-30℃ |
| InChI | 1S/C27H34ClNO2S/c1-6-7-14-32-25-22-15-20(18(2)3)10-13-23(22)29(17-19-8-11-21(28)12-9-19)24(25)16-27(4,5)26(30)31/h8-13,15,18H,6-7,14,16-17H2,1-5H3,(H,30,31) |
| InChI key | VFMGWQLOCZBFCK-UHFFFAOYSA-N |
| packaging【包装】 | 5 mg in Plastic ampoule |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 1 |
