MMP-2/MMP-3 Inhibitor III, PD166793-CAS 199850-67-4-Calbiochem

C₁₇H₁₈BrNO₄S

412.30

A cell-permeable biphenylsulfonylvaline compound that acts as a potent inhibitor against MMP-2, -3, and -13 (IC₅₀ = 47, 12, and 8 nM, respectively) and a weaker inhibitor against AMP deaminase (20% inhibition at 0.1 µM), MMP-1, -7, -9, and -14 (IC₅₀ = 6.1, 7.2, 7.9, and 0.24 µM, respectively). Shown to offer therapeutic benefits in vivo in various animal models of heart failure and diabetes.

Cell permeable: yes
Target IC₅₀: 47, 12, and 8 nM, against MMP-2, -3, and -13, respectively
Product does not compete with ATP.
Reversible: no
Primary Target
MMP-2, -3, and -13

Toxicity: Irritant (B)

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Paolocci, N., et al. 2006. J. Pharm. Exp. Ther.317, 506.
Zhou, Y.P., et al. 2005. Diabetes54, 2612.
Peterson, J.T., et al. 2001. Circulation103, 2303.
Spinale, F.G., et al. 1999. Circ. Res.85, 364.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

100

≥98% (TLC)

solid

Calbiochem^®

OK to freeze
protect from light

off-white

DMSO: 40 mg/mL
ethanol: 40 mg/mL

ambient

2-8℃

5 mg in Plastic ampoule

11 - Combustible Solids

WGK 2