NF-κB Activation Inhibitor III-CAS 380623-76-7-Calbiochem

C₁₀H₅ClN₄O₅S

328.69

MFCD00834007

A cell-permeable inhibitor of TNF-α-stimulated NF-κB activation and subsequent upregulation of MMP-9 in HT1080 cells (complete inhibition at 10 µM). The inhibition of MMP-9 upregulation correlates with a concomitant inhibition of TNF-α-dependent cell invasion. Does not affect TNF-α-induced AP-1 activity. The cellular target appears to be downstream of p38 activation.
A cell-permeable thiazoloamide compound that inhibits TNF-α-stimulated NF-κB activation and subsequent upregulation of MMP-9 in HT1080 cells (complete inhibition at 10 µM). The inhibition of MMP-9 upregulation correlates with a concomitant inhibition of TNF-α-dependent cell invasion. Does not affect TNF-α-induced AP-1 activity. The cellular target appears to be downstream of p38 activation.

Cell permeable: yes
Primary Target
TNF-α-stimulated NF-κB activation and upregulation of MMP-9
Product does not compete with ATP.
Reversible: no
Effective concentration: 10 µM for complete inhibition of TNF-α-stimulated NF-κB activation and subsequent upregulation of MMP-9 in HT1080 cells

Toxicity: Irritant (B)

Lee, H.Y., et al. 2005. Biochem. Biophys. Res. Commun.336, 716.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

100

≥98% (HPLC)

amorphous solid

Calbiochem^®

OK to freeze
protect from light

light yellow

DMSO: 10 mg/mL

ambient

2-8℃

5 mg in Glass bottle
Packaged under inert gas

11 - Combustible Solids

WGK 3