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PDE4D Inhibitor, GEBR-7b-Calbiochem
| 产品编号： | 4084125 |
| 规格： | The PDE4D Inhibitor, GEBR-7b controls the biological activity of PDE4D. This small molecule/inhibitor is primarily used for Cell Signaling applications. |
| 包装规格： | 5 MG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
PDE4D Inhibitor, GEBR-7b-Calbiochem
GEBR-7b, (E)-3-(cyclopentyloxy)-4-methoxybenzaldehyde, O-2-(2,6-dimethylmorpholino)-2-oxoethyl oxime
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C21H30N2O5 |
| Molecular weight | 390.47 |
| MDL number | MFCD28053503 |
| General description【一般描述】 | A cell permeable, potent, and selective oxime PDE4D inhibitor (IC50 = 0.67 µM) which displays much reduced activities toward other PDE4 isoforms. It is shown to cause a significant 40% increase in extracellular cAMP in the hippocampus of freely moving rats in vivo at 100 µM, but has no effect on Aβ levels. This compound elicits cognitive enhancement in vivo at the optimum dose of 0.003 mg/kg in both mice and rat models, and unlike rolipram, does not cause emesis-like behavior in rodents. |
| Warning【警告】 | Toxicity: Standard Handling (A) |
| Other Notes【其他说明】 | Bruno, O., et al. 2011. Br. J. Pharmacol.in press. Bruno, O., et al. 2009. J. Med. Chem.52, 6546. |
| Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥95% (HPLC) |
| form【形式】 | semisolid |
| manufacturer/tradename | Calbiochem® |
| storage condition【储存条件】 | OK to freeze protect from light |
| color【颜色】 | pale yellow |
| solubility【溶解性】 | DMSO: 100 mg/mL, clear, colorless |
| shipped in【运输】 | wet ice |
| storage temp.【储存温度】 | −20℃ |
| SMILES string | COC1=C(OC2CCCC2)C=C(/C([H])=N/OCC(N3CC(C)OC(C)C3)=O)C=C1 |
| packaging【包装】 | 5 mg in Glass bottle Packaged under inert gas |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 2 |
