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JNK Inhibitor V-CAS 345987-15-7-Calbiochem
| 产品编号： | 4084199 |
| 规格： | The JNK Inhibitor V, also referenced under CAS 345987-15-7, controls the biological activity of JNK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. |
| CAS NO： | 345987-15-7 |
| 包装规格： | 5 MG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
345987-15-7
JNK Inhibitor V-CAS 345987-15-7-Calbiochem
SAPK Inhibitor V, 1,3-Benzothiazol-2-yl-(2-((2-(3-pyridinyl)ethyl)amino)-4-pyrimidinyl)acetonitrile, AS601245
基本信息
| Empirical Formula【经验(实验)分子式】 | C20H16N6S |
| Molecular weight | 372.45 |
| General description【一般描述】 | A cell-permeable pyrimidinyl compound that displays anti-inflammatory properties. Acts as a potent, reversible, and ATP-competitive inhibitor of c-Jun N-terminal kinase (JNK, IC50 = 150, 220, and 70 nM for hJNK1, hJNK2, and hJNK3, respectively) with a 10- to 100-fold greater selectivity over a panel of 25 other commonly studied kinases (IC50 typically in the range of 1-10 µM or no effect at 10 µM). Its in vivo efficacy has been demonstrated in gerbils, mice, and rats via oral, i.v., or i.p. administration. |
| Biochem/physiol Actions【生化/生理作用】 | Cell permeable: yes Product competes with ATP. Primary Target hJNK 1, hJNK 2, hJNK 3 Reversible: yes Target IC50: 150, 220, and 70 nM for hJNK1, hJNK2, and hJNK3, respectively |
| Warning【警告】 | Toxicity: Harmful (C) |
| Reconstitution【重悬】 | Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. |
| Other Notes【其他说明】 | Gaillard, P., et al. 2005. J. Med. Chem.48, 4596. Carboni, S., et al. 2005. J. Neurochem.92, 1054. Ferrandi, C., et al. 2004. Br. J. Pharmacol.142, 953. Carboni, S., et al. 2004. J. Pharm. Exp. Ther.310, 25. Soluble in DMSO, aliquot & store at -20*C; stable for 3 months |
| Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥95% (sum of two isomers, HPLC) |
| form【形式】 | solid |
| manufacturer/tradename | Calbiochem® |
| storage condition【储存条件】 | OK to freeze desiccated (hygroscopic) protect from light |
| color【颜色】 | yellow |
| solubility【溶解性】 | DMSO: 10 mg/mL |
| shipped in【运输】 | ambient |
| storage temp.【储存温度】 | −20℃ |
| packaging【包装】 | 5 mg in Plastic ampoule Packaged under inert gas |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 1 |
