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Granzyme B human
| 产品编号： | 4084387 |
| 规格： | recombinant, expressed in insect cells, ≥90% (SDS-PAGE) |
| 包装规格： | 5 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Granzyme B human
GranzymeB
Granzyme-2
Lymphocyte protease
T-cell serine protease 1-3E
Cytotoxic T-lymphocyte proteinase 2
SECT
产品性质
| Quality Level【质量水平】 | 200 |
| biological source【生物来源】 | human |
| recombinant【重组】 | expressed in insect cells |
| Assay【测定】 | ≥90% (SDS-PAGE) |
| form【形式】 | lyophilized powder |
| potency【效能】 | >0.004 units/mg |
| Specific Activity | ≥40 units/μg |
| packaging【包装】 | pkg of 5 μg |
| UniProt accession no.【UniProt登记号】 | P10144 |
| shipped in【运输】 | wet ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... GZMB(3002) |
基本信息
| General description【一般描述】 | Granzyme B (GzmB) is a serine protease which is stored in granules of activated cytotoxic T cells and NK cells. GZMB codes for granzyme B. |
| Biochem/physiol Actions【生化/生理作用】 | Granzyme B is considered as the marker of activated CTLs (cytotoxic T-cells), which mediates target-cell apoptosis. It induces apoptosis in caspase-dependent and caspase-independent manner. After contact with target cells, granzyme B is directionally exocytosed, and then enters the target cell with assistance from perforin. Granzyme B specifically cleaves after Asp residues, and particularly processes and activates various pro-caspases. This induces apoptosis in the target cell. |
| Unit Definition【单位定义】 | One unit is defined as the amount of enzyme that hydrolyzes 1 pmol/min of IETD-AFC per min at 37℃ in 50 mM HEPES, pH 7.5 containing 10 mM CaCl2. |
| Physical form【外形】 | Lyophilized powder, containing HEPES buffer (original solution at pH 7.5) |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
