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Protein Kinase G Iβ human
| 产品编号： | 4084411 |
| 规格： | ≥95% (SDS-PAGE), recombinant, expressed in baculovirus infected Sf9 cells, buffered aqueous glycerol solution |
| 包装规格： | 5 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Protein Kinase G Iβ human
cyclic-Guanosine Monophosphate-dependent Protein Kinase 1β human
基本信息
| Enzyme Commission (EC) Number【酶学委员会(EC)编号】 | 2.7.11.12 ( BRENDA | IUBMB ) |
| MDL number | MFCD03458230 |
| NACRES | NA.54 |
| Application【应用】 | Protein Kinase G is a serine/threonine-specific protein kinase that is activated by cGMP. Protein Kinase G Iβ is used to induce apoptosis and inhibit cell proliferation. |
| Biochem/physiol Actions【生化/生理作用】 | Protein Kinase G Iβ induces apoptosis in certain cell lines such as human breast cancer cell lines MCF-7 and MDA-MB-468. It inhibits cell proliferation and induces apoptosis in colon cancer cell lines. |
| Unit Definition【单位定义】 | One unit will phosphorylate 1 micromole of VASPtide(RRKVSKQE) substrate per minute in 10 mM HEPES, pH 7.4, 5 mM MgCl2, 1 mM DTE and 0.2 mM EDTA. |
| Physical form【外形】 | Solution in 20 mM Tris buffer, pH 7.4, 1 mM EDTA, 1 mM β-mercaptoethanol, 100 mM NaCl, 10 U/ml Trasylol, and 50% glycerol. |
产品性质
| Quality Level【质量水平】 | 200 |
| recombinant【重组】 | expressed in baculovirus infected Sf9 cells |
| Assay【测定】 | ≥95% (SDS-PAGE) |
| form【形式】 | buffered aqueous glycerol solution |
| Specific Activity | ≥1.5 units/mg protein (20-fold stimulation by cGMP (5 μM)) |
| mol wt【分子量】 | 76 kDa (monomer) |
| UniProt accession no.【UniProt登记号】 | Q13976 |
| relevant disease(s)【相关疾病】 | cancer |
| shipped in【运输】 | wet ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... PRKG1(5592) |
安全信息
| Storage Class Code【储存分类代码】 | 10 - Combustible liquids |
| WGK | WGK 1 |
