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Interleukin-11 human
| 产品编号： | 4084467 |
| 规格： | >97% (SDS-PAGE), recombinant, expressed in baculovirus infected Sf21 cells, lyophilized powder, suitable for cell culture |
| 包装规格： | 5 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Interleukin-11 human
IL-11
基本信息
| MDL number | MFCD00212208 |
| NACRES | NA.32 |
| General description【一般描述】 | Interleukin-11 (IL-11) is synthesized by many mesenchymal origin cells like keratinocytes, synoviocytes, fibroblasts, bone marrow stromal cells, osteoblasts, and chondrocytes. The gene IL-11 (interleukin 11) is mapped to human chromosome 19q13.4. It is a secreted protein. |
| Biochem/physiol Actions【生化/生理作用】 | Interleukin 11 (IL-11) is involved in promoting tissue fibrosis and regulates the function of chondrocytes, synoviocytes, and B cells. It is also involved in bone metabolism and tissue remodeling. Interleukin-11, also called adipogenesis inhibitory factor (AGIF), is a pleotropic cytokine that acts on hematopoietic progenitor cells and stromal cells. Although recombinant human IL-11 has a predicted molecular mass of 19 kDa, it migrates as a 23 kDa band in SDS-PAGE. It is a functional homolog of IL-6, inducing the proliferation of certain plasmacytoma cell lines and acute phase protein secretion in the liver. IL-11 stimulates the production of erythrocytes, megakaryocytes, and T cell development of antibody producing B cells. |
| Physical form【外形】 | Lyophilized from a 0.2 μm filtered solution of PBS and EDTA with BSA as a carrier protein. |
| Analysis Note【分析说明】 | The biological activity is measured in a cell proliferation assay using T11, a subline of the IL-6-dependent murine plasmacytoma cell line T1165.85.2.1 that has been adapted to grow in IL-11. |
产品性质
| Quality Level【质量水平】 | 100 |
| biological source【生物来源】 | human |
| recombinant【重组】 | expressed in baculovirus infected Sf21 cells |
| Assay【测定】 | >97% (SDS-PAGE) |
| form【形式】 | lyophilized powder |
| potency【效能】 | 0.06-0.24 ng/mL ED50 |
| mol wt【分子量】 | 23 kDa |
| packaging【包装】 | pkg of 5 μg |
| technique(s) | cell culture | mammalian: suitable |
| impurities【杂质】 | endotoxin, tested |
| UniProt accession no.【UniProt登记号】 | P20809 |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... IL11(3589) |
安全信息
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
| Personal Protective Equipment【个人防护装备】 | Eyeshields, Gloves, type N95 (US) |
