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Anti-Endoglin Antibody, clone P3D1
产品别名
Anti-Endoglin Antibody, clone P3D1
CD105, Ancillary TGF-beta Receptor
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.41 |
| General description【一般描述】 | Endoglin is a homodimeric integral membrane glycoprotein comprised of 95 kDa subunit. Endoglin is a component of the TGF-B receptor system that functions as an ancillary receptor influencing binding of the Transforming Growth Factor beta (TGF-β) family ligands to signaling receptors. Endoglin binds TGF-B1 and TGF-B3 with high affinity but does not bind TGF-B2. Endoglin is expressed by vascular endothelial cells and syncytiotrophoblasts of placenta and is weakly expressed by stromalfibroblasts. It is also expressed by U937 cells and activated macrophages. Endoglin expression is up regulated on activated endothelium in tissues undergoing angiogenesis, such as in tumors, or in cases of wound healing or dermal inflammation. |
| Specificity【特异性】 | Reacts with human endoglin. |
| Immunogen【免疫原】 | Human resting umbilical vein endothelial cells. |
| Application【应用】 | Research Sub Category Growth Factors & Receptors Anti-Endoglin Antibody, clone P3D1 is an antibody against Endoglin for use in WB, IH, IC, IP, FC, ELISA. Research Category Signaling Immunohistochemistry: For use on acetone or paraformaldehyde fixed tissue. ELISA: A previous lot of this antibody was used in ELISA. Immunoprecipitation: A previous lot of this antibody was used in IP. Immunocytochemistry: A previous lot of this antibody was used in IC. Flow Cytometry: A previous lot of this antibody was used in FC. Optimal working dilutions must be determined by the end user. |
| Quality【质量】 | Routinely evaluated by Western Blot on Jurkat lysates. Western Blot Analysis: 1:500 dilution of this lot detected ENDOGLIN on 10 μg of Jurkat lysates. |
| Linkage【联系】 | Replaces: MAB2152 |
| Physical form【外形】 | Purified Format: Purified Purified mouse monoclonal IgG2a in 0.02M phosphate buffer, 0.25M sodium chloride, 0.1% sodium azide, pH 7.6 |
| Analysis Note【分析说明】 | Control Jurkat cell lysate |
| Other Notes【其他说明】 | Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration. |
产品性质
| Quality Level【质量水平】 | 100 |
| biological source【生物来源】 | mouse |
| antibody form【抗体形式】 | purified immunoglobulin |
| antibody product type | primary antibodies |
| clone【克隆】 | P3D1, monoclonal |
| species reactivity | mouse, human |
| species reactivity (predicted by homology) | rat |
| technique(s) | ELISA: suitable flow cytometry: suitable immunocytochemistry: suitable immunohistochemistry: suitable immunoprecipitation (IP): suitable western blot: suitable |
| isotype【同位素/亚型】 | IgG2a |
| NCBI accession no.【NCBI登记号】 | NM_000118.1 |
| UniProt accession no.【UniProt登记号】 | P17813 |
| shipped in【运输】 | wet ice |
产品说明
| Target description【目标描述】 | ~71 kDa |
| Storage and Stability【储存及稳定性】 | Stable at 2-8°C for up to 1 year from date of receipt. |
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 10 - Combustible liquids |
| WGK | WGK 2 |
