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PTEN human
产品别名
PTEN human
Phosphatidylinositol-3
PTEN
5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
Mutated in multiple advanced cancers 1
Phosphatase and tensin homolog
基本信息
| MDL number | MFCD03458266 |
| NACRES | NA.32 |
| Biochem/physiol Actions【生化/生理作用】 | PTEN, a tumor suppressor, has been implicated in a large number of human tumors and is conserved from humans to worms. Characterization of PTEN protein showed that it is a phosphatase that acts on proteins and on 3-phosphorylated phosphoinositides, and can therefore modulate signal-transduction pathways that involve lipid second messengers. Recent results indicate that at least part of its role is to regulate the activity of the serine/threonine kinase AKT/PKB, and thus influence cell survival signaling. Recombinant PTEN is purified by proprietary chromatographic techniques. |
| Physical form【外形】 | Sterile filtered liquid at 100 μg/ml. |
| Reconstitution【重悬】 | Centrifuge the vial prior to opening. Avoid freeze-thaw cycles. |
产品性质
| biological source【生物来源】 | human |
| recombinant【重组】 | expressed in E. coli |
| Assay【测定】 | ≥90% |
| form【形式】 | liquid |
| mol wt【分子量】 | ~86.0 kDa |
| packaging【包装】 | pkg of 5 μg |
| storage condition【储存条件】 | avoid repeated freeze/thaw cycles |
| impurities【杂质】 | <0.1 EU/μg |
| NCBI accession no.【NCBI登记号】 | P60484 |
| shipped in【运输】 | dry ice |
| storage temp.【储存温度】 | −70℃ |
| Gene Information | human ... PTEN(5728) |
安全信息
| Storage Class Code【储存分类代码】 | 10 - Combustible liquids |
| WGK | WGK 3 |
