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产品别名
83-45-4
sitostanol
stigmastanol; dihydrositosterol; (3β)-stigmastan-3-ol; (3β,5α)-stigmastan-3-ol
基本信息
| Empirical Formula【经验(实验)分子式】 | C29H52O |
| Molecular weight | 416.72 |
| NACRES | NA.25 |
| General description【一般描述】 | It is predominantly present in pine oil. Sitostanol is a plant stanol and a hydrogenated form of sitosterol. Sitostanol is a 5α-saturated sitosterol derivative. |
| Application【应用】 | Sitostanol is suitable for its use as a component in micelle preparation, used for cell culture and cellular uptake studies. It is also suitable for use in cell culture to study its effect on a T-helper-1 shift in peripheral blood mononuclear cells (PBMCs) from asthma patients. Sitostanol may be used in the preparation of binary phospholipid for thermodynamic studies and Brewster angle microscopy studies. It may also be used as a standard steroid in gas chromatography-mass spectrometry(GC-MS). |
| Biochem/physiol Actions【生化/生理作用】 | Sitostanol decreases cholesterol absorption. Its ratio with cholesterol is implicated in non-alcoholic fatty liver disease (NAFLD). The ratio also correlates with liver steatosis and inflammation. Sitostanol induces interferon γ production and T-helper response in peripheral blood mononuclear cells (PBMC) in asthma patients. It is a hypocholestremic agent as it decreases the micellar solubility and absorption of cholesterol. Plant stanols are structurally similar to cholesterol, hence it reduces the plasma level of LDL cholesterol. Sitostanol is known to possess hypolipidemic and antiatherogenic effects. Sitostanol lowers the intestinal absorption of cholesterol and serum cholesterol. |
产品性质
| Assay【测定】 | >99% (TLC) |
| form【形式】 | powder |
| manufacturer/tradename | Avanti Polar Lipids 700121P |
| shipped in【运输】 | dry ice |
| storage temp.【储存温度】 | −20℃ |
| InChI | 1S/C29H52O/c1-7-21(19(2)3)9-8-20(4)25-12-13-26-24-11-10-22-18-23(30)14-16-28(22,5)27(24)15-17-29(25,26)6/h19-27,30H,7-18H2,1-6H3/t20-,21-,22+,23+,24+,25-,26+,27+,28+,29-/m1/s1 |
| InChI key | LGJMUZUPVCAVPU-HRJGVYIJSA-N |
| packaging【包装】 | 5 mL Amber Glass Screw Cap Vial (700121P-5mg) |
安全信息
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
