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6-keto-5α-hydroxycholesterol
| 产品编号： | 4085075 |
| 规格： | 3β,5α-dihydroxy-cholestan-6-one, powder |
| CAS NO： | 13027-33-3 |
| 包装规格： | 5 MG |
| 产品类别： | 进口试剂 |
| 品牌： | Avanti |
| 优惠价： | 立即咨询 |
产品别名
13027-33-3
6-keto-5α-hydroxycholesterol
基本信息
| Empirical Formula【经验(实验)分子式】 | C27H46O3 |
| Molecular weight | 418.65 |
| NACRES | NA.25 |
| General description【一般描述】 | 6-keto-5α-hydroxycholesterol, also known as 6-oxo-cholestan-3β,5α-diol (OCDO), is synthesized from the oxidation of 5β, 6β-epoxycholesterol in the presence of enzyme cholesterol epoxide hydrolase. It is also synthesized from cholestane-3β,5α,6β-triol by the enzyme 11β-hydroxysteroid dehydrogenase type II . The enzyme 11β-hydroxysteroid dehydrogenase type I catalyzes the reduction of OCDO to cholestane-3β,5α,6β-triol. |
| Biochem/physiol Actions【生化/生理作用】 | 6-keto-5α-hydroxycholesterol favors tumor progression. cholestan-6-oxo-3β,5α-diolelicits cytotoxicity towards human bronchial 16-HBE cells and plays a key role in mediating cell necrosis post ozone exposure. It is an oncometabolite, which promotes breast cancer progression and also blocks chemotaxis mediated by polymorphonuclear leukocytes. |
产品性质
| Assay【测定】 | >99% (TLC) |
| form【形式】 | powder |
| manufacturer/tradename | Avanti Polar Lipids 700140P |
| shipped in【运输】 | dry ice |
| storage temp.【储存温度】 | −20℃ |
| InChI | 1S/C27H46O3/c1-17(2)7-6-8-18(3)21-9-10-22-20-15-24(29)27(30)16-19(28)11-14-26(27,5)23(20)12-13-25(21,22)4/h17-23,28,30H,6-16H2,1-5H3/t18-,19+,20+,21-,22+,23+,25-,26-,27+/m1/s1 |
| InChI key | SJZZRXMQSAXCFD-ZCBMJONGSA-N |
| packaging【包装】 | 5 mL Amber Glass Screw Cap Vial (700140P-5mg) |
安全信息
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
