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Anti-CrkL Antibody, clone 5-6
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.41 |
| General description【一般描述】 | CRKL is a 39kDa adaptor protein with one SH2 and two SH3 binding domains. CRKL is the major protein which is tyrosine phosphorylated in response to BCR/ABL (chronic myelogenous leukemia) and growth factor activation. In myeloid cells, it binds to proteins such as paxillin, p130cas and p120 cbl. CRKL aslo appears to bind ABL and SOS. The antibody does not cross-react with CRKI or CRKII. |
| Specificity【特异性】 | Other species have not been tested. the C-terminal SH3 of Human CRKL |
| Immunogen【免疫原】 | Full length GST fusion protein corresponding to Human CRKL Epitope: Full-length |
| Application【应用】 | Research Sub Category Cytoskeletal Signaling Detect CrkL using this Anti-CrkL Antibody, clone 5-6 validated for use in IP, WB, IH. Research Category Signaling |
| Quality【质量】 | Routinely evaluated by Western Blot on K562 cell lysate. Western Blot Analysis: Antibody detected CRKL in 15 μg of K562 cell lysate. |
| Physical form【外形】 | Purified in 0.1M Tris-Glycine (pH7.4) 150mM NaCl with 0.05% NaN3. Format: Purified Protein G Purified |
| Analysis Note【分析说明】 | Control Western Blot and Immunoprecipitation: K562 cell lysate Immunocytochemistry: Hela cells |
| Legal Information【法律信息】 | UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
| Quality Level【质量水平】 | 100 |
| biological source【生物来源】 | mouse |
| antibody form【抗体形式】 | purified antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | 5-6, monoclonal |
| species reactivity | human, mouse, rat |
| manufacturer/tradename | Upstate® |
| technique(s) | immunohistochemistry: suitable immunoprecipitation (IP): suitable western blot: suitable |
| isotype【同位素/亚型】 | IgG2aκ |
| NCBI accession no.【NCBI登记号】 | NM_005207 |
| UniProt accession no.【UniProt登记号】 | P46109 |
| shipped in【运输】 | wet ice |
| Gene Information | human ... CRKL(1399) |
产品说明
| Target description【目标描述】 | 39kDa |
| Storage and Stability【储存及稳定性】 | Maintain at 2-8°C in undiluted aliquots for up to 1 year after date of receipt. |
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 2 |
