您的位置：首页 > 产品中心 > Anti-HDAC3 Antibody, clone 3G6
Anti-HDAC3 Antibody, clone 3G6
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.41 |
| General description【一般描述】 | Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. HDAC3 belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. HDAC3 is regarded as a potential tumor suppressor gene. |
| Specificity【特异性】 | Predicted to cross-react with rat and chicken based on sequence homology HDAC3 |
| Immunogen【免疫原】 | peptide (NEFYDGDHDNDKESDVEI) corresponding to amino acids 411-428 of human HDAC3 |
| Application【应用】 | Research Sub Category Histones Anti-HDAC3 Antibody, clone 3G6 is a Mouse Monoclonal Antibody for detection of HDAC3 also known as histone deacetylase 3 & has been tested in IP, WB, ICC. Research Category Epigenetics & Nuclear Function |
| Quality【质量】 | routinely evaluated by immunoprecipitation/HDAC |
| Physical form【外形】 | 0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30%. Format: Purified Protein G Purified |
| Analysis Note【分析说明】 | Control HL-60 cell lysate |
| Legal Information【法律信息】 | UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
| Quality Level【质量水平】 | 100 |
| biological source【生物来源】 | mouse |
| antibody form【抗体形式】 | purified antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | 3G6, monoclonal |
| species reactivity | human, bovine, mouse, hamster |
| manufacturer/tradename | Upstate® |
| technique(s) | immunocytochemistry: suitable immunoprecipitation (IP): suitable western blot: suitable |
| isotype【同位素/亚型】 | IgG2a |
| NCBI accession no.【NCBI登记号】 | NM_003883 |
| UniProt accession no.【UniProt登记号】 | O15379 |
| shipped in【运输】 | wet ice |
产品说明
| Target description【目标描述】 | 49-53kDa |
| Storage and Stability【储存及稳定性】 | 2 years at -20°C |
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 10 - Combustible liquids |
| WGK | WGK 1 |
