您的位置：首页 > 产品中心 > Anti-VEGF Antibody, clone VG1
Anti-VEGF Antibody, clone VG1
产品别名
Anti-VEGF Antibody, clone VG1
Vascular permeability factor, vascular endothelial growth factor, vascular endothelial growth factor A, vascular endothelial growth factor isoform VEGF165
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.41 |
| General description【一般描述】 | VEGF (Vascular endothelial growth factor, VEGFA, VEGF-A), a dimeric ligand, is among the most potent angiogenic mitogens. VEGF is secreted by tumor cells and other cells exposed to hypoxia. VEGF is a highly specific mitogen for vascular endothelial cells. Seven VEGF isoforms (a, b, c, d, e, f, g) are generated as a result of alternative splicing from a single VEGF gene. The most commonly studied isoforms are VEGF121, VEGF165, and VEGF189 (f, d and b, respectively) All seven isoforms differ in their molecular mass and in biological properties such as their ability to bind to cell-surface heparan-sulfate proteoglycans. The expression of VEGF is potentiated and is secreted by tumor cells in response to hypoxia, by activated oncogenes, and by a variety of cytokines. |
| Specificity【特异性】 | Detects the 121, 165, and 189 amino acid isoforms of VEGF. |
| Immunogen【免疫原】 | Recombinant human VEGF 189aa isoform |
| Application【应用】 | Detect VEGF using this Anti-VEGF Antibody, clone VG1 validated for use in WB. Research Sub Category Growth Factors & Receptors Research Category Signaling |
| Quality【质量】 | Evaluated by Western Blot in NIH/3T3 cell lysate. Western Blot Analysis: A 1:500 dilution of this antibody detected VEGF on 10 µg of NIH/3T3 cell lysate. |
| Linkage【联系】 | Replaces: MAB3734 |
| Physical form【外形】 | Unpurified Unpurified mouse monoclonal IgG1κ in ascites fluid containing no preservatives. |
| Analysis Note【分析说明】 | Control NIH/3T3 cell lysate |
产品性质
| Quality Level【质量水平】 | 100 |
| biological source【生物来源】 | mouse |
| antibody form【抗体形式】 | ascites fluid |
| clone【克隆】 | VG1, monoclonal |
| species reactivity | rat, human, mouse |
| technique(s) | western blot: suitable |
| isotype【同位素/亚型】 | IgG1κ |
| NCBI accession no.【NCBI登记号】 | NP_033531.3 |
| UniProt accession no.【UniProt登记号】 | P15692 |
| shipped in【运输】 | wet ice |
产品说明
| Target description【目标描述】 | Approx. 12-28 kDa |
| Storage and Stability【储存及稳定性】 | Stable for 12 months at -20°C from date of receipt. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. |
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 10 - Combustible liquids |
| WGK | WGK 1 |
