BRG1-mt, K798R human

NA.26

The SMARCA4 (SWI/SNF (SWItch/sucrose non-fermentable) related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4) gene is mapped to human chromosome 19p13.2. The protein encoded by the SMARCA4 gene is an ATPases transcription activator with multisubunits (12-15).

BRG1 is an essential component of the SWI/SNF chromatin remodeling complexes and is implicated in multiple functions through its interaction with different proteins, including the tumor suppressor protein pRb, serine-threonine kinase LKB1, and other transcription factors. Mutation of lysine to arginine at position 798 in the DNA-dependent ATPase domain of BRG1 a) failed to restore normal growth to swi2- cells, b) reduced its ability to repress c-fos transcription, and c) reduced CIITA (class II transactivator) induction and enhanced the rate of induction of the interferon-g-responsive GBP-1 gene.

Clear and colorless frozen liquid solution

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.

human

expressed in insect cells

≥80% (SDS-PAGE)

frozen liquid

~185 kDa

pkg of 5 μg

avoid repeated freeze/thaw cycles

300  μg/mL

clear
colorless

NM_003072

P51532

dry ice

−70℃

human ... SMARCA4(6597)

10 - Combustible liquids

WGK 1