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ET-18-OCH3-CAS 70641-51-9-Calbiochem

产品编号:4085410
规格:A cell-permeable and reversible cytotoxic agent that shows selective cytocidal activity against neoplastic cells and virally transformed cells.
CAS NO:70641-51-9
包装规格:5 MG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品编号包装单位单价(元)国内现货国外库存询价单
40854105 MG1940
产品别名

70641-51-9

ET-18-OCH3-CAS 70641-51-9-Calbiochem

Edelfosine, 1-O-Octadecyl-2-O-methyl-rac-glycero-3-phosphorylcholine

Edelfosine, 1-O-Octadecyl-2-O-methyl- rac-glycero-3-phosphorylcholine

基本信息
Empirical Formula【经验(实验)分子式】
C27H58NO6P
Molecular weight
523.73
MDL number
MFCD00135190
General description【一般描述】
A cell-permeable and reversible cytotoxic agent that shows selective cytocidal activity against neoplastic cells and virally transformed cells. Selectively inhibits phosphatidylinositol-specific phospholipase C (PI-PLC, IC50 = 9.6 µM) but does not inhibit phosphatidylcholine-specific PLC or PLD. Inhibits protein kinase C from various leukemic cells. Also promotes rapid and selective apoptosis in human leukemic cells. Has strong antitumor and anticancer properties.
A cell-permeable and reversible cytotoxic agent that shows selective cytocidal activity against neoplastic cells and virally transformed cells. Selectively inhibits phosphatidylinositol-specific phospholipase C (PI-PLC, IC50 = 9.6 µM) but does not inhibit phosphatidylcholine-specific PLC or PLD. Promotes apoptosis in mitogen-activated, but not resting, T lymphocytes in a dose- and time-dependent manner. Also promotes rapid and selective apoptosis in human leukemic cells.
Biochem/physiol Actions【生化/生理作用】
Cell permeable: yes
Product does not compete with ATP.
Target IC50: 9.6 µM against phosphatidylinositol-specific phospholipase C (PI-PLC)
Reversible: yes
Primary Target
PI-PLC
Caution【注意】
Material may form micelles in aqueous stock solutions, which may affect experimental results.
Warning【警告】
Toxicity: Carcinogenic / Teratogenic (D)
Reconstitution【重悬】
Following reconstitution in ethanol, aliquot and freeze (-20°C). Ethanol stock solutions are stable for up to 3 months at -20°C. Unstable in aqueous solution; reconstitute just prior to use.
Other Notes【其他说明】
Harguindey, J., et al. 2000. Apoptosis5, 87.
Cabaner, C., et al. 1999. Br. J. Pharmacol. 127, 813.
Powis, G., and Phil, D. 1994. Cancer Metastasis Rev.13, 91.
Helfman, D., et al. 1993. Cancer Res. 53, 2955.
Mollinedo, F., et al. 1993. Biochem. Biophys. Res. Commun. 192, 603.
Powis, G., et al. 1992. Cancer Res.52, 2835.
Oishi, K., et al. 1988. Biochem. Biophys. Res. Commun.157, 1000.
Legal Information【法律信息】
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
产品性质
Quality Level【质量水平】
100
Assay【测定】
≥95% (TLC)
form【形式】
solid
manufacturer/tradename
Calbiochem®
storage condition【储存条件】
OK to freeze
color【颜色】
white
solubility【溶解性】
DMSO: 5 mg/mL
ethanol: 5 mg/mL
chloroform: 50 mg/mL
water: soluble
shipped in【运输】
ambient
storage temp.【储存温度】
−20℃
InChI
1S/C27H58NO6P/c1-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-23-32-25-27(31-5)26-34-35(29,30)33-24-22-28(2,3)4/h27H,6-26H2,1-5H3
InChI key
MHFRGQHAERHWKZ-UHFFFAOYSA-N
packaging【包装】
5 mg in Plastic ampoule
安全信息
Storage Class Code【储存分类代码】
11 - Combustible Solids
WGK
WGK 3
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